Temporal summation and refractoriness in hypothalamic reward neurons as measured by self-stimulation behavior

Nicole Schupf Smith; Edgar E. Coons

doi:10.1126/science.169.3947.782

Temporal summation and refractoriness in hypothalamic reward neurons as measured by self-stimulation behavior

Nicole Schupf Smith, Edgar E. Coons

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

A neurophysiological technique of double-pulse stimulation has been applied to freely moving rats with chronic indwelling electrodes in the hypothalamic reward area. Self-stimulation thresholds, measured as a function of the interpulse interval, generated curves with time constants characteristic of refractory periods and temporal synoptic summation. The results indicate a way of studying central neuronal processes for which the overt behavior of the animal is the dependent variable.

Original language	English (US)
Pages (from-to)	782-785
Number of pages	4
Journal	Science
Volume	169
Issue number	3947
DOIs	https://doi.org/10.1126/science.169.3947.782
State	Published - 1970

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title = "Temporal summation and refractoriness in hypothalamic reward neurons as measured by self-stimulation behavior",

abstract = "A neurophysiological technique of double-pulse stimulation has been applied to freely moving rats with chronic indwelling electrodes in the hypothalamic reward area. Self-stimulation thresholds, measured as a function of the interpulse interval, generated curves with time constants characteristic of refractory periods and temporal synoptic summation. The results indicate a way of studying central neuronal processes for which the overt behavior of the animal is the dependent variable.",

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AB - A neurophysiological technique of double-pulse stimulation has been applied to freely moving rats with chronic indwelling electrodes in the hypothalamic reward area. Self-stimulation thresholds, measured as a function of the interpulse interval, generated curves with time constants characteristic of refractory periods and temporal synoptic summation. The results indicate a way of studying central neuronal processes for which the overt behavior of the animal is the dependent variable.

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Temporal summation and refractoriness in hypothalamic reward neurons as measured by self-stimulation behavior

Abstract

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