Temporally graded requirement for protein synthesis following memory reactivation

Maria H. Milekic, Cristina M. Alberini

Research output: Contribution to journalArticlepeer-review


Learning of new information is transformed into long-lasting memory through a process known as consolidation, which requires protein synthesis. Classical theory held that once consolidated, memory was insensitive to disruption. However, old memories that are insensitive to protein synthesis inhibitors can become vulnerable if they are recalled (reactivated). These findings led to a new hypothesis that when an old memory is reactivated, it again becomes labile and, similar to a newly formed memory, requires a process of reconsolidation in order to be maintained. Here, we show that the requirement for protein synthesis of a reactivated memory is evident only when the memory is recent. In fact, memory vulnerability decreases as the time between the original training and the recall increases.

Original languageEnglish (US)
Pages (from-to)521-525
Number of pages5
Issue number3
StatePublished - Oct 24 2002

ASJC Scopus subject areas

  • General Neuroscience


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