Terahertz pulse-altered gene networks in human induced pluripotent stem cells

Takehiro Tachizaki, Reiko Sakaguchi, Shiho Terada, Ken Ichiro Kamei, Hideki Hirori

Research output: Contribution to journalArticlepeer-review


Terahertz (THz) irradiation has been exploited in biomedical applications involving non-invasive manipulation of living cells. We developed an apparatus for studying the effects of THz pulse irradiation on living human induced pluripotent stem cells. The THz pulse of the maximum electric field reached 0.5 MV/cm and was applied for one hour with 1 kHz repetition to the entire cell–culture area, a diameter of 1 mm. RNA sequencing of global gene-expression revealed that many THz-regulated genes were driven by zinc–finger transcription factors. Combined with a consideration of the interactions of metal ions and a THz electric field, these results imply that the local intracellular concentration of metal ions, such as Zn2+, was changed by the effective electrical force of our THz pulse.

Original languageEnglish (US)
Pages (from-to)6078-6081
Number of pages4
JournalOptics Letters
Issue number21
StatePublished - Nov 1 2020

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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