Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein

Research output: Contribution to journalArticlepeer-review

Abstract

A group of novel Bcl-xL/Bak antagonists, based on a terephthalamide scaffold, were designed to mimic the α-helical region of the Bak peptide. Good in vitro inhibition potencies in disrupting the Bak/Bcl-xL complex have been observed (terephthalamide 4, Ki=0.78±0.07 μM).

Original languageEnglish (US)
Pages (from-to)1375-1379
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number6
DOIs
StatePublished - Mar 22 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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