Tetra-arylborate lipophilic anions as targeting groups

Kishore K. Gaddale Devanna, Justyna M. Gawel, Tracy A. Prime, Filip Cvetko, Cristiane Benincá, Stuart T. Caldwell, Alexander Negoda, Andrew Harrison, Andrew M. James, Evgeny V. Pavlov, Michael P. Murphy, Richard C. Hartley

Research output: Contribution to journalArticlepeer-review

Abstract

Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.

Original languageEnglish (US)
Pages (from-to)3147-3150
Number of pages4
JournalChemical Communications
Volume57
Issue number25
DOIs
StatePublished - Mar 28 2021

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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