Tetra-arylborate lipophilic anions as targeting groups

Kishore K. Gaddale Devanna; Justyna M. Gawel; Tracy A. Prime; Filip Cvetko; Cristiane Benincá; Stuart T. Caldwell; Alexander Negoda; Andrew Harrison; Andrew M. James; Evgeny V. Pavlov; Michael P. Murphy; Richard C. Hartley

doi:10.1039/d0cc07924c

Tetra-arylborate lipophilic anions as targeting groups

Kishore K. Gaddale Devanna, Justyna M. Gawel, Tracy A. Prime, Filip Cvetko, Cristiane Benincá, Stuart T. Caldwell, Alexander Negoda, Andrew Harrison, Andrew M. James, Evgeny V. Pavlov, Michael P. Murphy, Richard C. Hartley

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.

Original language	English (US)
Pages (from-to)	3147-3150
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	25
DOIs	https://doi.org/10.1039/d0cc07924c
State	Published - Mar 28 2021

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d0cc07924c

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title = "Tetra-arylborate lipophilic anions as targeting groups",

abstract = "Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.",

author = "{Gaddale Devanna}, {Kishore K.} and Gawel, {Justyna M.} and Prime, {Tracy A.} and Filip Cvetko and Cristiane Beninc{\'a} and Caldwell, {Stuart T.} and Alexander Negoda and Andrew Harrison and James, {Andrew M.} and Pavlov, {Evgeny V.} and Murphy, {Michael P.} and Hartley, {Richard C.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

year = "2021",

month = mar,

day = "28",

doi = "10.1039/d0cc07924c",

language = "English (US)",

volume = "57",

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journal = "Chemical Communications",

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T1 - Tetra-arylborate lipophilic anions as targeting groups

AU - Gaddale Devanna, Kishore K.

AU - Gawel, Justyna M.

AU - Prime, Tracy A.

AU - Cvetko, Filip

AU - Benincá, Cristiane

AU - Caldwell, Stuart T.

AU - Negoda, Alexander

AU - Harrison, Andrew

AU - James, Andrew M.

AU - Pavlov, Evgeny V.

AU - Murphy, Michael P.

AU - Hartley, Richard C.

PY - 2021/3/28

Y1 - 2021/3/28

N2 - Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.

AB - Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.

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UR - http://www.scopus.com/inward/citedby.url?scp=85103246990&partnerID=8YFLogxK

U2 - 10.1039/d0cc07924c

DO - 10.1039/d0cc07924c

M3 - Article

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AN - SCOPUS:85103246990

SN - 1359-7345

VL - 57

SP - 3147

EP - 3150

JO - Chemical Communications

JF - Chemical Communications

IS - 25

ER -

Tetra-arylborate lipophilic anions as targeting groups

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ASJC Scopus subject areas

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