Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding

Toshihiro Aya; Andrew D. Hamilton

doi:10.1016/S0960-894X(03)00551-1

Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding

Toshihiro Aya, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A family of tetrabiphenylporphyrin-based receptors has been synthesized. Receptor 7 showed sub-nanomolar affinity (K_d=0.67 nM) in binding to the surface of cytochrome c. In addition, a stoichiometric amount of the receptor 7 caused a lowering in the T_m of cytochrome c from 85 to 35°C.

Original language	English (US)
Pages (from-to)	2651-2654
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	16
DOIs	https://doi.org/10.1016/S0960-894X(03)00551-1
State	Published - Aug 18 2003

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(03)00551-1

Cite this

@article{e8343a341b6343c39747421a7b8d819e,

title = "Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding",

abstract = "A family of tetrabiphenylporphyrin-based receptors has been synthesized. Receptor 7 showed sub-nanomolar affinity (Kd=0.67 nM) in binding to the surface of cytochrome c. In addition, a stoichiometric amount of the receptor 7 caused a lowering in the Tm of cytochrome c from 85 to 35°C.",

author = "Toshihiro Aya and Hamilton, {Andrew D.}",

note = "Funding Information: This work was supported by the National Institutes of Health (GM35208).",

year = "2003",

month = aug,

day = "18",

doi = "10.1016/S0960-894X(03)00551-1",

language = "English (US)",

volume = "13",

pages = "2651--2654",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "16",

}

TY - JOUR

T1 - Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding

AU - Aya, Toshihiro

AU - Hamilton, Andrew D.

N1 - Funding Information: This work was supported by the National Institutes of Health (GM35208).

PY - 2003/8/18

Y1 - 2003/8/18

N2 - A family of tetrabiphenylporphyrin-based receptors has been synthesized. Receptor 7 showed sub-nanomolar affinity (Kd=0.67 nM) in binding to the surface of cytochrome c. In addition, a stoichiometric amount of the receptor 7 caused a lowering in the Tm of cytochrome c from 85 to 35°C.

AB - A family of tetrabiphenylporphyrin-based receptors has been synthesized. Receptor 7 showed sub-nanomolar affinity (Kd=0.67 nM) in binding to the surface of cytochrome c. In addition, a stoichiometric amount of the receptor 7 caused a lowering in the Tm of cytochrome c from 85 to 35°C.

UR - http://www.scopus.com/inward/record.url?scp=0038149100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038149100&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(03)00551-1

DO - 10.1016/S0960-894X(03)00551-1

M3 - Article

C2 - 12873486

AN - SCOPUS:0038149100

SN - 0960-894X

VL - 13

SP - 2651

EP - 2654

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this