Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding

Toshihiro Aya, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

A family of tetrabiphenylporphyrin-based receptors has been synthesized. Receptor 7 showed sub-nanomolar affinity (Kd=0.67 nM) in binding to the surface of cytochrome c. In addition, a stoichiometric amount of the receptor 7 caused a lowering in the Tm of cytochrome c from 85 to 35°C.

Original languageEnglish (US)
Pages (from-to)2651-2654
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number16
DOIs
StatePublished - Aug 18 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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