The association between measures of sleepiness and subjective cognitive decline symptoms in a diverse population of cognitively normal older adults

Anthony Q. Briggs; Carolina Boza-Calvo; Mark A. Bernard; Henry Rusinek; Rebecca A. Betensky; Arjun V. Masurkar

doi:10.1177/13872877251331237

The association between measures of sleepiness and subjective cognitive decline symptoms in a diverse population of cognitively normal older adults

Anthony Q. Briggs, Carolina Boza-Calvo, Mark A. Bernard, Henry Rusinek, Rebecca A. Betensky, Arjun V. Masurkar

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Subjective cognitive decline (SCD) is associated with preclinical Alzheimer's disease (AD). Suboptimal sleep is also a risk factor for cognitive decline, but with unclear relationship to SCD. We conducted a retrospective cross-sectional study in a biracial research cohort of 148 cognitively normal older adults who underwent quantification of SCD (Cognitive Change Index; CCI), sleepiness (Epworth Sleepiness Scale; ESS), depression (Geriatric Depression Scale; GDS), and amyloid/tau PET. ESS score was associated with total, amnestic, and non-amnestic CCI scores, after adjustment for GDS, amyloid/tau burden, and race. This supports future longitudinal work on how sleepiness impacts SCD outcomes.

Original language	English (US)
Pages (from-to)	740-744
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	105
Issue number	3
DOIs	https://doi.org/10.1177/13872877251331237
State	Published - Jun 2025

Keywords

Alzheimer's disease
amnestic
cognitive aging
cognitive dysfunction
depression
excessive sleepiness
imaging biomarkers
non-amnestic
subjective cognitive decline

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.1177/13872877251331237

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abstract = "Subjective cognitive decline (SCD) is associated with preclinical Alzheimer's disease (AD). Suboptimal sleep is also a risk factor for cognitive decline, but with unclear relationship to SCD. We conducted a retrospective cross-sectional study in a biracial research cohort of 148 cognitively normal older adults who underwent quantification of SCD (Cognitive Change Index; CCI), sleepiness (Epworth Sleepiness Scale; ESS), depression (Geriatric Depression Scale; GDS), and amyloid/tau PET. ESS score was associated with total, amnestic, and non-amnestic CCI scores, after adjustment for GDS, amyloid/tau burden, and race. This supports future longitudinal work on how sleepiness impacts SCD outcomes.",

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author = "Briggs, {Anthony Q.} and Carolina Boza-Calvo and Bernard, {Mark A.} and Henry Rusinek and Betensky, {Rebecca A.} and Masurkar, {Arjun V.}",

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AU - Boza-Calvo, Carolina

AU - Bernard, Mark A.

AU - Rusinek, Henry

AU - Betensky, Rebecca A.

AU - Masurkar, Arjun V.

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/6

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N2 - Subjective cognitive decline (SCD) is associated with preclinical Alzheimer's disease (AD). Suboptimal sleep is also a risk factor for cognitive decline, but with unclear relationship to SCD. We conducted a retrospective cross-sectional study in a biracial research cohort of 148 cognitively normal older adults who underwent quantification of SCD (Cognitive Change Index; CCI), sleepiness (Epworth Sleepiness Scale; ESS), depression (Geriatric Depression Scale; GDS), and amyloid/tau PET. ESS score was associated with total, amnestic, and non-amnestic CCI scores, after adjustment for GDS, amyloid/tau burden, and race. This supports future longitudinal work on how sleepiness impacts SCD outcomes.

AB - Subjective cognitive decline (SCD) is associated with preclinical Alzheimer's disease (AD). Suboptimal sleep is also a risk factor for cognitive decline, but with unclear relationship to SCD. We conducted a retrospective cross-sectional study in a biracial research cohort of 148 cognitively normal older adults who underwent quantification of SCD (Cognitive Change Index; CCI), sleepiness (Epworth Sleepiness Scale; ESS), depression (Geriatric Depression Scale; GDS), and amyloid/tau PET. ESS score was associated with total, amnestic, and non-amnestic CCI scores, after adjustment for GDS, amyloid/tau burden, and race. This supports future longitudinal work on how sleepiness impacts SCD outcomes.

KW - Alzheimer's disease

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KW - depression

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The association between measures of sleepiness and subjective cognitive decline symptoms in a diverse population of cognitively normal older adults

Abstract

Keywords

ASJC Scopus subject areas

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