The avascular zone and neuronal remodeling of the fovea in Parkinson disease

Shahnaz Miri; Eric M. Shrier; Sofya Glazman; Yin Ding; Ivan Selesnick; Piotr B. Kozlowski; Ivan Bodis-Wollner

doi:10.1002/acn3.146

The avascular zone and neuronal remodeling of the fovea in Parkinson disease

Shahnaz Miri, Eric M. Shrier, Sofya Glazman, Yin Ding, Ivan Selesnick, Piotr B. Kozlowski, Ivan Bodis-Wollner

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Inner foveal thinning and intracellular alpha-synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha-synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non-DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 healthy controls using retinal fluorescein angiography and optical coherence tomography. The size of the foveal avascular zone inversely correlates with foveal thinning. Foveal thinning highly correlates with motor impairment and also disease duration. Quantifying capillary and neuronal remodeling could serve as biological markers.

Original language	English (US)
Pages (from-to)	196-201
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1002/acn3.146
State	Published - Feb 2015

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1002/acn3.146

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@article{7991110438f44e4883d8c99853b2b809,

title = "The avascular zone and neuronal remodeling of the fovea in Parkinson disease",

abstract = "Inner foveal thinning and intracellular alpha-synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha-synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non-DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 healthy controls using retinal fluorescein angiography and optical coherence tomography. The size of the foveal avascular zone inversely correlates with foveal thinning. Foveal thinning highly correlates with motor impairment and also disease duration. Quantifying capillary and neuronal remodeling could serve as biological markers.",

author = "Shahnaz Miri and Shrier, {Eric M.} and Sofya Glazman and Yin Ding and Ivan Selesnick and Kozlowski, {Piotr B.} and Ivan Bodis-Wollner",

note = "Funding Information: This work was supported indirectly by the Parkinson Study Group, the Michael J. Fox Foundation, and by the Research to Prevent Blindness. Funding Information: This work was supported indirectly by the Parkinson Study Group, the Michael J. Fox Foundation, and by the Research to Prevent Blindness. We thank Galina Glazman, Pawel Kuczaj, and Bella Berger for help in data collection; Bill Lytton, MD and Olie Westheimer, MA for editing the paper. Publisher Copyright: {\textcopyright} 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.",

year = "2015",

month = feb,

doi = "10.1002/acn3.146",

language = "English (US)",

volume = "2",

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AU - Miri, Shahnaz

AU - Shrier, Eric M.

AU - Glazman, Sofya

AU - Ding, Yin

AU - Selesnick, Ivan

AU - Kozlowski, Piotr B.

AU - Bodis-Wollner, Ivan

N1 - Funding Information: This work was supported indirectly by the Parkinson Study Group, the Michael J. Fox Foundation, and by the Research to Prevent Blindness. Funding Information: This work was supported indirectly by the Parkinson Study Group, the Michael J. Fox Foundation, and by the Research to Prevent Blindness. We thank Galina Glazman, Pawel Kuczaj, and Bella Berger for help in data collection; Bill Lytton, MD and Olie Westheimer, MA for editing the paper. Publisher Copyright: © 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

PY - 2015/2

Y1 - 2015/2

N2 - Inner foveal thinning and intracellular alpha-synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha-synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non-DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 healthy controls using retinal fluorescein angiography and optical coherence tomography. The size of the foveal avascular zone inversely correlates with foveal thinning. Foveal thinning highly correlates with motor impairment and also disease duration. Quantifying capillary and neuronal remodeling could serve as biological markers.

AB - Inner foveal thinning and intracellular alpha-synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha-synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non-DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 healthy controls using retinal fluorescein angiography and optical coherence tomography. The size of the foveal avascular zone inversely correlates with foveal thinning. Foveal thinning highly correlates with motor impairment and also disease duration. Quantifying capillary and neuronal remodeling could serve as biological markers.

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The avascular zone and neuronal remodeling of the fovea in Parkinson disease

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