TY - JOUR
T1 - The Bacillus subtilis endospore
T2 - Assembly and functions of the multilayered coat
AU - Mckenney, Peter T.
AU - Driks, Adam
AU - Eichenberger, Patrick
N1 - Funding Information:
We apologize to colleagues whose work could not be cited in full owing to space limitations. Work in P.E.’s laboratory is supported by grant GM081571 from the US National Institutes of Health (NIH). Work in A.D.’s laboratory is supported by NIH grants R21AI097934 and R01AI093493, and HDTRA1-11-1-0051 from the US Department of Defense.
PY - 2013/1
Y1 - 2013/1
N2 - Sporulation in Bacillus subtilis involves an asymmetric cell division followed by differentiation into two cell types, the endospore and the mother cell. The endospore coat is a multilayered shell that protects the bacterial genome during stress conditions and is composed of dozens of proteins. Recently, fluorescence microscopy coupled with high-resolution image analysis has been applied to the dynamic process of coat assembly and has shown that the coat is organized into at least four distinct layers. In this Review, we provide a brief summary of B. subtilis sporulation, describe the function of the spore surface layers and discuss the recent progress that has improved our understanding of the structure of the endospore coat and the mechanisms of coat assembly.
AB - Sporulation in Bacillus subtilis involves an asymmetric cell division followed by differentiation into two cell types, the endospore and the mother cell. The endospore coat is a multilayered shell that protects the bacterial genome during stress conditions and is composed of dozens of proteins. Recently, fluorescence microscopy coupled with high-resolution image analysis has been applied to the dynamic process of coat assembly and has shown that the coat is organized into at least four distinct layers. In this Review, we provide a brief summary of B. subtilis sporulation, describe the function of the spore surface layers and discuss the recent progress that has improved our understanding of the structure of the endospore coat and the mechanisms of coat assembly.
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U2 - 10.1038/nrmicro2921
DO - 10.1038/nrmicro2921
M3 - Review article
C2 - 23202530
AN - SCOPUS:84871292768
SN - 1740-1526
VL - 11
SP - 33
EP - 44
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 1
ER -