The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Dane D. Jensen, Cody B. Godfrey, Christian Niklas, Meritxell Canals, Martina Kocan, Daniel P. Poole, Jane E. Murphy, Farzad Alemi, Graeme S. Cottrell, Christoph Korbmacher, Nevin A. Lambert, Nigel W. Bunnett, Carlos U. Corvera

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.

Original languageEnglish (US)
Pages (from-to)22942-22960
Number of pages19
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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