The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations

Susana Nery; Gord Fishell; Joshua G. Corbin

doi:10.1038/nn971

The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations

Susana Nery, Gord Fishell, Joshua G. Corbin

Center for Genomics and Systems Biology

Research output: Contribution to journal › Article › peer-review

Abstract

During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is a progenitor region that is distinct from both the MGE and LGE. Notably, CGE cells showed a unique in vivo pattern of migration, and the CGE contributed cells to nuclei distinct from those populated by the MGE and LGE. Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE.

Original language	English (US)
Pages (from-to)	1279-1287
Number of pages	9
Journal	Nature Neuroscience
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nn971
State	Published - Dec 1 2002

ASJC Scopus subject areas

General Neuroscience

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title = "The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations",

abstract = "During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is a progenitor region that is distinct from both the MGE and LGE. Notably, CGE cells showed a unique in vivo pattern of migration, and the CGE contributed cells to nuclei distinct from those populated by the MGE and LGE. Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE.",

author = "Susana Nery and Gord Fishell and Corbin, {Joshua G.}",

note = "Funding Information: We thank the Fishell lab, H. Wichterle, J. Goldman and I. Zohn for critical reading and M. Rutlin and Y.Y. Huang for technical assistance. We thank A. Langston and E. Na for generating the Dlx2-tau-lacZ transgenic line and the following for their gifts of reagents: J.R. Stringer, A. Joyner, F. Guillemot, J. Rubenstein, J. Nathans, S. Arber, P. Charnay, U. Eriksson and M. Sheng. S.N. is supported by PRAXIS XXI through the Gulbenkian Ph.D. program and J.C. is a recipient of a NIH postdoctoral fellowship NS10962-03. This work was supported by a National Institutes of Health grant (RO1 NS39007-03) and a March of Dimes basic research grant to G.F.",

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N2 - During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is a progenitor region that is distinct from both the MGE and LGE. Notably, CGE cells showed a unique in vivo pattern of migration, and the CGE contributed cells to nuclei distinct from those populated by the MGE and LGE. Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE.

AB - During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is a progenitor region that is distinct from both the MGE and LGE. Notably, CGE cells showed a unique in vivo pattern of migration, and the CGE contributed cells to nuclei distinct from those populated by the MGE and LGE. Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE.

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The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations

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