The chromatin fiber: Multiscale problems and approaches

Gungor Ozer, Antoni Luque, Tamar Schlick

Research output: Contribution to journalReview articlepeer-review

Abstract

The structure of chromatin, affected by many factors from DNA linker lengths to posttranslational modifications, is crucial to the regulation of eukaryotic cells. Combined experimental and computational methods have led to new insights into its structural and dynamical features, from interactions due to the flexible core histone tails or linker histones to the physical mechanism driving the formation of chromosomal domains. Here we present a perspective of recent advances in chromatin modeling techniques at the atomic, mesoscopic, and chromosomal scales with a view toward developing multiscale computational strategies to integrate such findings. Innovative modeling methods that connect molecular to chromosomal scales are crucial for interpreting experiments and eventually deciphering the complex dynamic organization and function of chromatin in the cell.

Original languageEnglish (US)
Pages (from-to)124-139
Number of pages16
JournalCurrent Opinion in Structural Biology
Volume31
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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