The CircumVent Project: a CPAP/O2 helmet solution for non-invasive ventilation using an implementation research framework

Aimalohi A. Ahonkhai, Adesola Z. Musa, André A. Fenton, Muktar H. Aliyu, Igho Ofotokun, Alex Hornstein, Baba M. Musa, Nnamdi Nwosu, Ifeoma Ulasi, Samuel Ajayi, Catherine Falade, Adedamola Dada, Aliyu Abdu, Mogaji Sunday, Adenike Odewabi, Muyiwa K. Rotimi, Onome Ogueh, Alan Steinbach, Gbenga Ogedegbe, Babatunde L. SalakoOliver C. Ezechi

Research output: Contribution to journalArticlepeer-review


Background: Acute respiratory failure, a major cause of death in COVID-19, is managed with high-flow oxygen therapy via invasive mechanical ventilation. In resource-limited settings like Nigeria, the shortage of ventilators and oxygen supply makes this option challenging. Evidence-based non-invasive alternatives to mechanical ventilation such as the use of continuous positive airway pressure (CPAP) devices exist, but there have been concerns that non-invasive ventilation may expose healthcare workers to infection from aerosolized dispersion of SARS-CoV-2. We propose to evaluate the feasibility, adaptability and acceptability of a CPAP/O2 helmet solution for non-invasive ventilation among patients with COVID-19 and health workers in eight COVID-19 treatment and isolation centers in Nigeria. Methods: The study will occur in 4 stages: (1) convene a Steering Committee of key stakeholders and recruit implementation sites; (2) use the integrated Promoting Action on Research Implementation in Health Services (i-PARiHS) framework to guide a needs assessment of treatment centers’ capacity to use high-flow oxygen therapy to treat COVID-19 patients and utilize the findings to develop an implementation strategy for the use of a CPAP/O2 helmet solution; (3) build infrastructure to support training and data monitoring processes and to develop implementation protocols to evaluate the adaptability of the strategy for the use of the CPAP/O2 helmet; and (4) train health workers, distribute a CPAP/O2 helmet solution for non-invasive ventilation, pilot test the implementation strategy, and assess feasibility of its use and acceptability that includes monitoring altered risk of SARS-CoV-2 infection among healthcare workers. Discussion: The CPAP/O2 helmet solution for non-invasive ventilation in Nigeria can serve as a scalable model for resource-poor countries, and beyond the COVID-19 pandemic, has the potential to be deployed for the treatment of pneumonia and other respiratory diseases. Trial registration: NCT04929691. Registered June 18, 2021—retrospectively registered,

Original languageEnglish (US)
Article number93
JournalImplementation Science Communications
Issue number1
StatePublished - Dec 2021


  • Implementation science
  • Nigeria
  • Non-invasive ventilation
  • SARS-CoV-2, COVID-19 infection

ASJC Scopus subject areas

  • Health Policy
  • Health Informatics
  • Public Health, Environmental and Occupational Health


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