TY - JOUR
T1 - The CircumVent Project
T2 - a CPAP/O2 helmet solution for non-invasive ventilation using an implementation research framework
AU - Ahonkhai, Aimalohi A.
AU - Musa, Adesola Z.
AU - Fenton, André A.
AU - Aliyu, Muktar H.
AU - Ofotokun, Igho
AU - Hornstein, Alex
AU - Musa, Baba M.
AU - Nwosu, Nnamdi
AU - Ulasi, Ifeoma
AU - Ajayi, Samuel
AU - Falade, Catherine
AU - Dada, Adedamola
AU - Abdu, Aliyu
AU - Sunday, Mogaji
AU - Odewabi, Adenike
AU - Rotimi, Muyiwa K.
AU - Ogueh, Onome
AU - Steinbach, Alan
AU - Ogedegbe, Gbenga
AU - Salako, Babatunde L.
AU - Ezechi, Oliver C.
N1 - Funding Information:
We are grateful to the 40+ volunteers who worked to develop the concept of the CPAP/OHelmet system within the Ventilator Project ( www.ventilatorproject.org ), especially John Gridley who guided and helped the team to navigate the medical device and funding spaces and Deepika Grover who helped with communications and the search for funding. 2
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Background: Acute respiratory failure, a major cause of death in COVID-19, is managed with high-flow oxygen therapy via invasive mechanical ventilation. In resource-limited settings like Nigeria, the shortage of ventilators and oxygen supply makes this option challenging. Evidence-based non-invasive alternatives to mechanical ventilation such as the use of continuous positive airway pressure (CPAP) devices exist, but there have been concerns that non-invasive ventilation may expose healthcare workers to infection from aerosolized dispersion of SARS-CoV-2. We propose to evaluate the feasibility, adaptability and acceptability of a CPAP/O2 helmet solution for non-invasive ventilation among patients with COVID-19 and health workers in eight COVID-19 treatment and isolation centers in Nigeria. Methods: The study will occur in 4 stages: (1) convene a Steering Committee of key stakeholders and recruit implementation sites; (2) use the integrated Promoting Action on Research Implementation in Health Services (i-PARiHS) framework to guide a needs assessment of treatment centers’ capacity to use high-flow oxygen therapy to treat COVID-19 patients and utilize the findings to develop an implementation strategy for the use of a CPAP/O2 helmet solution; (3) build infrastructure to support training and data monitoring processes and to develop implementation protocols to evaluate the adaptability of the strategy for the use of the CPAP/O2 helmet; and (4) train health workers, distribute a CPAP/O2 helmet solution for non-invasive ventilation, pilot test the implementation strategy, and assess feasibility of its use and acceptability that includes monitoring altered risk of SARS-CoV-2 infection among healthcare workers. Discussion: The CPAP/O2 helmet solution for non-invasive ventilation in Nigeria can serve as a scalable model for resource-poor countries, and beyond the COVID-19 pandemic, has the potential to be deployed for the treatment of pneumonia and other respiratory diseases. Trial registration: NCT04929691. Registered June 18, 2021—retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04929691
AB - Background: Acute respiratory failure, a major cause of death in COVID-19, is managed with high-flow oxygen therapy via invasive mechanical ventilation. In resource-limited settings like Nigeria, the shortage of ventilators and oxygen supply makes this option challenging. Evidence-based non-invasive alternatives to mechanical ventilation such as the use of continuous positive airway pressure (CPAP) devices exist, but there have been concerns that non-invasive ventilation may expose healthcare workers to infection from aerosolized dispersion of SARS-CoV-2. We propose to evaluate the feasibility, adaptability and acceptability of a CPAP/O2 helmet solution for non-invasive ventilation among patients with COVID-19 and health workers in eight COVID-19 treatment and isolation centers in Nigeria. Methods: The study will occur in 4 stages: (1) convene a Steering Committee of key stakeholders and recruit implementation sites; (2) use the integrated Promoting Action on Research Implementation in Health Services (i-PARiHS) framework to guide a needs assessment of treatment centers’ capacity to use high-flow oxygen therapy to treat COVID-19 patients and utilize the findings to develop an implementation strategy for the use of a CPAP/O2 helmet solution; (3) build infrastructure to support training and data monitoring processes and to develop implementation protocols to evaluate the adaptability of the strategy for the use of the CPAP/O2 helmet; and (4) train health workers, distribute a CPAP/O2 helmet solution for non-invasive ventilation, pilot test the implementation strategy, and assess feasibility of its use and acceptability that includes monitoring altered risk of SARS-CoV-2 infection among healthcare workers. Discussion: The CPAP/O2 helmet solution for non-invasive ventilation in Nigeria can serve as a scalable model for resource-poor countries, and beyond the COVID-19 pandemic, has the potential to be deployed for the treatment of pneumonia and other respiratory diseases. Trial registration: NCT04929691. Registered June 18, 2021—retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04929691
KW - Implementation science
KW - Nigeria
KW - Non-invasive ventilation
KW - SARS-CoV-2, COVID-19 infection
UR - http://www.scopus.com/inward/record.url?scp=85130101783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130101783&partnerID=8YFLogxK
U2 - 10.1186/s43058-021-00193-y
DO - 10.1186/s43058-021-00193-y
M3 - Article
AN - SCOPUS:85130101783
SN - 2662-2211
VL - 2
JO - Implementation Science Communications
JF - Implementation Science Communications
IS - 1
M1 - 93
ER -