The critical role of the central nervous system (pro)renin receptor in regulating systemic blood pressure

Quanbin Xu, Dane D. Jensen, Hua Peng, Yumei Feng

Research output: Contribution to journalReview articlepeer-review

Abstract

The systemic renin–angiotensin system (RAS) has long been recognized as a critically important system in blood pressure (BP) regulation. However, extensive evidence has shown that a majority of RAS components are also present in many tissues and play indispensable roles in BP regulation. Here, we review evidence that RAS components, notably including the newly identified (pro)renin receptor (PRR), are present in the brain and are essential for the central regulation of BP. Binding of the PRR to its ligand, prorenin or renin, increases BP and promotes progression of cardiovascular diseases in an angiotensin II-dependent and -independent manner, establishing the PRR a promising antihypertensive drug target. We also review the existing PRR blockers, including handle region peptide and PRO20, and propose a rationale for blocking prorenin/PRR activation as a therapeutic approach that does not affect the actions of the PRR in vacuolar H+-ATPase and development. Finally, we summarize categories of currently available antihypertensive drugs and consider future perspectives.

Original languageEnglish (US)
Pages (from-to)126-134
Number of pages9
JournalPharmacology and Therapeutics
Volume164
DOIs
StatePublished - Aug 1 2016

Keywords

  • (Pro)renin receptor
  • (Pro)renin receptor antagonists
  • Antihypertensive drugs
  • Brain
  • Hypertension
  • Prorenin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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