The design of a biochip: A self-assembling molecular-scale memory device

Bruce H. Robinson, Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


A design for a biochip memory device based on known materials and existing principles is presented. The fabrication of this memory system relies on the self-assembly of the nucleic acid junction system, which acts as the scaffolding for a molecular wire consisting of polyacetylene-like units. A molecular switch to control current is described which is based on the formation of a charge - transfer complex. A molecular-scale bit is presented which is based on oxidation - reduction potentials of metal atoms or clusters. The readable 'bit' which can be made of these components has a volume of 3×107 Å3 and should operate at electronic speeds over short distances.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalProtein Engineering, Design and Selection
Issue number4
StatePublished - Aug 1987


  • Biochip
  • Macromolecular design
  • Molecular electronics
  • Nucleic acid junctions
  • Self-assembly

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Molecular Biology


Dive into the research topics of 'The design of a biochip: A self-assembling molecular-scale memory device'. Together they form a unique fingerprint.

Cite this