The design of a biochip: A self-assembling molecular-scale memory device

Bruce H. Robinson; Nadrian C. Seeman

doi:10.1093/protein/1.4.295

The design of a biochip: A self-assembling molecular-scale memory device

Bruce H. Robinson, Nadrian C. Seeman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A design for a biochip memory device based on known materials and existing principles is presented. The fabrication of this memory system relies on the self-assembly of the nucleic acid junction system, which acts as the scaffolding for a molecular wire consisting of polyacetylene-like units. A molecular switch to control current is described which is based on the formation of a charge - transfer complex. A molecular-scale bit is presented which is based on oxidation - reduction potentials of metal atoms or clusters. The readable 'bit' which can be made of these components has a volume of 3×10⁷ Å³ and should operate at electronic speeds over short distances.

Original language	English (US)
Pages (from-to)	295-300
Number of pages	6
Journal	Protein Engineering, Design and Selection
Volume	1
Issue number	4
DOIs	https://doi.org/10.1093/protein/1.4.295
State	Published - Aug 1987

Keywords

Biochip
Macromolecular design
Molecular electronics
Nucleic acid junctions
Self-assembly

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biochemistry
Molecular Biology

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10.1093/protein/1.4.295

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title = "The design of a biochip: A self-assembling molecular-scale memory device",

abstract = "A design for a biochip memory device based on known materials and existing principles is presented. The fabrication of this memory system relies on the self-assembly of the nucleic acid junction system, which acts as the scaffolding for a molecular wire consisting of polyacetylene-like units. A molecular switch to control current is described which is based on the formation of a charge - transfer complex. A molecular-scale bit is presented which is based on oxidation - reduction potentials of metal atoms or clusters. The readable 'bit' which can be made of these components has a volume of 3×107 {\AA}3 and should operate at electronic speeds over short distances.",

keywords = "Biochip, Macromolecular design, Molecular electronics, Nucleic acid junctions, Self-assembly",

author = "Robinson, {Bruce H.} and Seeman, {Nadrian C.}",

note = "Funding Information: We wish to thank Larry Dalton, James Mayer, Kathleen McDonough and James Gladden for valuable discussions and suggestions. N.C.S. was the recipient of a NIH Research Career Development Award. This work has been supported by NIH grants GM-29S54 and ES-00117 to N.C.S., a gram from The Research Corporation to B.H.R., and NSF grant PCM-82-16762 to B.H.R.",

year = "1987",

month = aug,

doi = "10.1093/protein/1.4.295",

language = "English (US)",

volume = "1",

pages = "295--300",

journal = "Protein Engineering, Design and Selection",

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publisher = "Oxford University Press",

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T2 - A self-assembling molecular-scale memory device

AU - Robinson, Bruce H.

AU - Seeman, Nadrian C.

N1 - Funding Information: We wish to thank Larry Dalton, James Mayer, Kathleen McDonough and James Gladden for valuable discussions and suggestions. N.C.S. was the recipient of a NIH Research Career Development Award. This work has been supported by NIH grants GM-29S54 and ES-00117 to N.C.S., a gram from The Research Corporation to B.H.R., and NSF grant PCM-82-16762 to B.H.R.

PY - 1987/8

Y1 - 1987/8

N2 - A design for a biochip memory device based on known materials and existing principles is presented. The fabrication of this memory system relies on the self-assembly of the nucleic acid junction system, which acts as the scaffolding for a molecular wire consisting of polyacetylene-like units. A molecular switch to control current is described which is based on the formation of a charge - transfer complex. A molecular-scale bit is presented which is based on oxidation - reduction potentials of metal atoms or clusters. The readable 'bit' which can be made of these components has a volume of 3×107 Å3 and should operate at electronic speeds over short distances.

AB - A design for a biochip memory device based on known materials and existing principles is presented. The fabrication of this memory system relies on the self-assembly of the nucleic acid junction system, which acts as the scaffolding for a molecular wire consisting of polyacetylene-like units. A molecular switch to control current is described which is based on the formation of a charge - transfer complex. A molecular-scale bit is presented which is based on oxidation - reduction potentials of metal atoms or clusters. The readable 'bit' which can be made of these components has a volume of 3×107 Å3 and should operate at electronic speeds over short distances.

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KW - Macromolecular design

KW - Molecular electronics

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The design of a biochip: A self-assembling molecular-scale memory device

Abstract

Keywords

ASJC Scopus subject areas

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