TY - JOUR
T1 - The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques
AU - Alexopoulos, Palaiologos
AU - Madu, Chisom
AU - Wollstein, Gadi
AU - Schuman, Joel S.
N1 - Funding Information:
This study was supported by National Institutes of Health (Bethesda, MD, United States) R01-EY013178 (JS) and U01-EY033001 (JS). An unrestricted grant from Research to Prevent Blindness (New York, NY, United States) to the Department of Ophthalmology, NYU Langone Health, NYU Grossman School of Medicine, New York, NY, United States.
Funding Information:
JS: Aerie Pharmaceuticals, Inc. and Opticient: consultant/advisor and equity owner. BrightFocus Foundation and National Eye Institute: grant support. Boehringer Ingelheim, Perfuse, Inc., Regeneron, Inc., and SLACK Incorporated: consultant/advisor. Carl Zeiss Meditec: patents/royalty/consultant/advisor. Massachusetts Eye and Ear Infirmary and Massachusetts Institute of Technology, New York University, Tufts University, and University of Pittsburgh: intellectual property. Ocugenix: equity owner, and patents/royalty. Ocular Therapeutix, Inc.: consultant/advisor and equity owner. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher Copyright:
Copyright © 2022 Alexopoulos, Madu, Wollstein and Schuman.
PY - 2022/6/30
Y1 - 2022/6/30
N2 - The field of ophthalmic imaging has grown substantially over the last years. Massive improvements in image processing and computer hardware have allowed the emergence of multiple imaging techniques of the eye that can transform patient care. The purpose of this review is to describe the most recent advances in eye imaging and explain how new technologies and imaging methods can be utilized in a clinical setting. The introduction of optical coherence tomography (OCT) was a revolution in eye imaging and has since become the standard of care for a plethora of conditions. Its most recent iterations, OCT angiography, and visible light OCT, as well as imaging modalities, such as fluorescent lifetime imaging ophthalmoscopy, would allow a more thorough evaluation of patients and provide additional information on disease processes. Toward that goal, the application of adaptive optics (AO) and full-field scanning to a variety of eye imaging techniques has further allowed the histologic study of single cells in the retina and anterior segment. Toward the goal of remote eye care and more accessible eye imaging, methods such as handheld OCT devices and imaging through smartphones, have emerged. Finally, incorporating artificial intelligence (AI) in eye images has the potential to become a new milestone for eye imaging while also contributing in social aspects of eye care.
AB - The field of ophthalmic imaging has grown substantially over the last years. Massive improvements in image processing and computer hardware have allowed the emergence of multiple imaging techniques of the eye that can transform patient care. The purpose of this review is to describe the most recent advances in eye imaging and explain how new technologies and imaging methods can be utilized in a clinical setting. The introduction of optical coherence tomography (OCT) was a revolution in eye imaging and has since become the standard of care for a plethora of conditions. Its most recent iterations, OCT angiography, and visible light OCT, as well as imaging modalities, such as fluorescent lifetime imaging ophthalmoscopy, would allow a more thorough evaluation of patients and provide additional information on disease processes. Toward that goal, the application of adaptive optics (AO) and full-field scanning to a variety of eye imaging techniques has further allowed the histologic study of single cells in the retina and anterior segment. Toward the goal of remote eye care and more accessible eye imaging, methods such as handheld OCT devices and imaging through smartphones, have emerged. Finally, incorporating artificial intelligence (AI) in eye images has the potential to become a new milestone for eye imaging while also contributing in social aspects of eye care.
KW - adaptive optics
KW - artificial intelligence – AI
KW - full field OCT
KW - optical coherence tomography
KW - optical coherence tomography (angiography) (OCTA)
KW - visible light OCT
UR - http://www.scopus.com/inward/record.url?scp=85134166910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85134166910&partnerID=8YFLogxK
U2 - 10.3389/fmed.2022.891369
DO - 10.3389/fmed.2022.891369
M3 - Review article
AN - SCOPUS:85134166910
SN - 2296-858X
VL - 9
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 891369
ER -