The Discovery of Potent SHP2 Inhibitors with Anti-Proliferative Activity in Breast Cancer Cell Lines

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Antiproliferative Activity 100%
• IC50 66%
• Cell Proliferation 33%
• Carcinogenesis 33%
• Enzyme 33%
• Active Site 33%
• Phosphatase 33%
• Anticancer 33%
• Cell Viability 33%
• Protein Tyrosine Phosphatase 33%

Keyphrases

• SHP2 Inhibitor 100%
• Catalytic Pocket 16%
• Cyclic System 16%
• Phenoxazine 16%
• Breast Cancer Cell Proliferation 16%
• SHP-1 16%
• Anti-breast Cancer 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Acridine 20%
• Protein Tyrosine Phosphatase SHP 2 20%