The discriminatory power of differential receptor arrays is improved by prescreening - A demonstration in the analysis of tachykinins and similar peptides

Aaron T. Wright; Nicola Y. Edwards; Eric V. Anslyn; John T. McDevitt

doi:10.1002/anie.200701236

The discriminatory power of differential receptor arrays is improved by prescreening - A demonstration in the analysis of tachykinins and similar peptides

Aaron T. Wright, Nicola Y. Edwards, Eric V. Anslyn, John T. McDevitt

Research output: Contribution to journal › Article › peer-review

Abstract

(Graph Presented) Patterning pain: Six strong-binding receptors for the decapeptide tachykinin neurotransmitter α-neurokinin were identified by screening a solid-supported library. Solution-phase studies with these six receptors metalated with three different metal salts in a 96-well plate array followed by principal component analysis showed the array's ability to recognize and discriminate substance P and α-neurokinin, as well as three similar peptides.

Original language	English (US)
Pages (from-to)	8212-8215
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	43
DOIs	https://doi.org/10.1002/anie.200701236
State	Published - 2007

Keywords

Arrays
Pattern recognition
Peptides
Sensors
Supramolecular chemistry

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200701236

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The discriminatory power of differential receptor arrays is improved by prescreening - A demonstration in the analysis of tachykinins and similar peptides. / Wright, Aaron T.; Edwards, Nicola Y.; Anslyn, Eric V. et al.
In: Angewandte Chemie - International Edition, Vol. 46, No. 43, 2007, p. 8212-8215.

Research output: Contribution to journal › Article › peer-review

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AU - McDevitt, John T.

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AB - (Graph Presented) Patterning pain: Six strong-binding receptors for the decapeptide tachykinin neurotransmitter α-neurokinin were identified by screening a solid-supported library. Solution-phase studies with these six receptors metalated with three different metal salts in a 96-well plate array followed by principal component analysis showed the array's ability to recognize and discriminate substance P and α-neurokinin, as well as three similar peptides.

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The discriminatory power of differential receptor arrays is improved by prescreening - A demonstration in the analysis of tachykinins and similar peptides

Abstract

Keywords

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