The discriminatory power of differential receptor arrays is improved by prescreening - A demonstration in the analysis of tachykinins and similar peptides

Aaron T. Wright, Nicola Y. Edwards, Eric V. Anslyn, John T. McDevitt

Research output: Contribution to journalArticle

Abstract

(Graph Presented) Patterning pain: Six strong-binding receptors for the decapeptide tachykinin neurotransmitter α-neurokinin were identified by screening a solid-supported library. Solution-phase studies with these six receptors metalated with three different metal salts in a 96-well plate array followed by principal component analysis showed the array's ability to recognize and discriminate substance P and α-neurokinin, as well as three similar peptides.

Original languageEnglish (US)
Pages (from-to)8212-8215
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number43
DOIs
StatePublished - 2007

Keywords

  • Arrays
  • Pattern recognition
  • Peptides
  • Sensors
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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