The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy

Jerome K. Percus; Ora E. Percus; Martin Markowitz; David D. Ho; Michele Di Mascio; Alan S. Perelson

doi:10.1016/S0092-8240(02)00095-2

The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy

Jerome K. Percus, Ora E. Percus, Martin Markowitz, David D. Ho, Michele Di Mascio, Alan S. Perelson

Mathematics

Research output: Contribution to journal › Article › peer-review

Abstract

Human immunodeficiency virus type 1 (HIV-1) infected patients treated with combination antiretroviral therapy frequently have the level of HIV-1 RNA detectable in plasma driven below the lower limit of detection of current assays, 50 copies ml^-1. Patients may continue to exhibit viral loads (VLs) below the assay limit for years, yet on some occasions the VL may be above the limit of detection. Whether these 'blips' in VL are simply assay errors or are indicative of intermittent episodes of increased viral replication is of great clinical concern. By analyzing the occurrence of viral blips in 123 treated HIV-infected patients, we show that patients do not share a common probability distribution of blip amplitude and thus reject the hypothesis that blips are solely due to assay variation.

Original language	English (US)
Pages (from-to)	263-277
Number of pages	15
Journal	Bulletin of Mathematical Biology
Volume	65
Issue number	2
DOIs	https://doi.org/10.1016/S0092-8240(02)00095-2
State	Published - Mar 2003

ASJC Scopus subject areas

General Neuroscience
Immunology
General Mathematics
General Biochemistry, Genetics and Molecular Biology
General Environmental Science
Pharmacology
General Agricultural and Biological Sciences
Computational Theory and Mathematics

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10.1016/S0092-8240(02)00095-2

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title = "The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy",

abstract = "Human immunodeficiency virus type 1 (HIV-1) infected patients treated with combination antiretroviral therapy frequently have the level of HIV-1 RNA detectable in plasma driven below the lower limit of detection of current assays, 50 copies ml-1. Patients may continue to exhibit viral loads (VLs) below the assay limit for years, yet on some occasions the VL may be above the limit of detection. Whether these 'blips' in VL are simply assay errors or are indicative of intermittent episodes of increased viral replication is of great clinical concern. By analyzing the occurrence of viral blips in 123 treated HIV-infected patients, we show that patients do not share a common probability distribution of blip amplitude and thus reject the hypothesis that blips are solely due to assay variation.",

author = "Percus, {Jerome K.} and Percus, {Ora E.} and Martin Markowitz and Ho, {David D.} and {Di Mascio}, Michele and Perelson, {Alan S.}",

note = "Funding Information: Portions of this work were done under the auspices of the U.S. Department of Energy. This work was supported by NIH grants: AI28433, AI40387, AI47033. We thank the referee for valuable comments. ",

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doi = "10.1016/S0092-8240(02)00095-2",

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AU - Percus, Jerome K.

AU - Percus, Ora E.

AU - Markowitz, Martin

AU - Ho, David D.

AU - Di Mascio, Michele

AU - Perelson, Alan S.

N1 - Funding Information: Portions of this work were done under the auspices of the U.S. Department of Energy. This work was supported by NIH grants: AI28433, AI40387, AI47033. We thank the referee for valuable comments.

PY - 2003/3

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N2 - Human immunodeficiency virus type 1 (HIV-1) infected patients treated with combination antiretroviral therapy frequently have the level of HIV-1 RNA detectable in plasma driven below the lower limit of detection of current assays, 50 copies ml-1. Patients may continue to exhibit viral loads (VLs) below the assay limit for years, yet on some occasions the VL may be above the limit of detection. Whether these 'blips' in VL are simply assay errors or are indicative of intermittent episodes of increased viral replication is of great clinical concern. By analyzing the occurrence of viral blips in 123 treated HIV-infected patients, we show that patients do not share a common probability distribution of blip amplitude and thus reject the hypothesis that blips are solely due to assay variation.

AB - Human immunodeficiency virus type 1 (HIV-1) infected patients treated with combination antiretroviral therapy frequently have the level of HIV-1 RNA detectable in plasma driven below the lower limit of detection of current assays, 50 copies ml-1. Patients may continue to exhibit viral loads (VLs) below the assay limit for years, yet on some occasions the VL may be above the limit of detection. Whether these 'blips' in VL are simply assay errors or are indicative of intermittent episodes of increased viral replication is of great clinical concern. By analyzing the occurrence of viral blips in 123 treated HIV-infected patients, we show that patients do not share a common probability distribution of blip amplitude and thus reject the hypothesis that blips are solely due to assay variation.

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The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy

Abstract

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