TY - JOUR
T1 - The DRD4 VNTR polymorphism influences reactivity to smoking cues
AU - Hutchison, Kent E.
AU - LaChance, Heather
AU - Niaura, Raymond
AU - Bryan, Angela
AU - Smolen, Andrew
PY - 2002
Y1 - 2002
N2 - Recent research has indicated that craving for tobacco can be reliably elicited by exposure to smoking cues, suggesting that cue-elicited craving for tobacco may be a useful phenotype for research on genetic factors related to nicotine dependence. Given the potential role of dopamine in cue-elicited craving, the authors examined whether the DRD4 VNTR polymorphism is associated with cue-elicited craving for tobacco. Participants who were homozygous or heterozygous for the 7 repeat (or longer) allele were classified as DRD4 L, and all other participants were classified as DRD4 S. Participants were exposed to smoking cues before smoking either high-nicotine cigarettes or control cigarettes. Analyses suggested that participants in the L group demonstrated significantly greater craving, more arousal, less positive affect, and more attention to the smoking cues than did the participants in the S group.
AB - Recent research has indicated that craving for tobacco can be reliably elicited by exposure to smoking cues, suggesting that cue-elicited craving for tobacco may be a useful phenotype for research on genetic factors related to nicotine dependence. Given the potential role of dopamine in cue-elicited craving, the authors examined whether the DRD4 VNTR polymorphism is associated with cue-elicited craving for tobacco. Participants who were homozygous or heterozygous for the 7 repeat (or longer) allele were classified as DRD4 L, and all other participants were classified as DRD4 S. Participants were exposed to smoking cues before smoking either high-nicotine cigarettes or control cigarettes. Analyses suggested that participants in the L group demonstrated significantly greater craving, more arousal, less positive affect, and more attention to the smoking cues than did the participants in the S group.
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U2 - 10.1037/0021-843X.111.1.134
DO - 10.1037/0021-843X.111.1.134
M3 - Article
C2 - 11866166
AN - SCOPUS:0036169193
SN - 0021-843X
VL - 111
SP - 134
EP - 143
JO - Journal of abnormal psychology
JF - Journal of abnormal psychology
IS - 1
ER -