The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

C. A. Rushlow, A. Hogan, S. M. Pinchin, K. M. Howe, M. Lardelli, D. Ish-Horowicz

Research output: Contribution to journalArticle

Abstract

The Drosophila segmentation gene, hairy (h), acts to regulate embryonic segmentation and bristle pattern. We present the DNA sequence of the h gene and of h cDNAs, thereby deducing the organization of the h transcripts. The h gene encodes a 337 amino acid protein that acts in both embryonic segmentation and adult bristle patterning. The h protein includes a domain that shows extensive similarity to a domain of the proto-oncogene N-myc that may be involved in DNA binding and/or protein dimerization. We discuss mechanisms of h action as a transcriptional regulator.

Original languageEnglish (US)
Pages (from-to)3095-3103
Number of pages9
JournalThe EMBO journal
Volume8
Issue number10
DOIs
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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