The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

C. A. Rushlow; A. Hogan; S. M. Pinchin; K. M. Howe; M. Lardelli; D. Ish-Horowicz

doi:10.1002/j.1460-2075.1989.tb08461.x

The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

C. A. Rushlow, A. Hogan, S. M. Pinchin, K. M. Howe, M. Lardelli, D. Ish-Horowicz

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

The Drosophila segmentation gene, hairy (h), acts to regulate embryonic segmentation and bristle pattern. We present the DNA sequence of the h gene and of h cDNAs, thereby deducing the organization of the h transcripts. The h gene encodes a 337 amino acid protein that acts in both embryonic segmentation and adult bristle patterning. The h protein includes a domain that shows extensive similarity to a domain of the proto-oncogene N-myc that may be involved in DNA binding and/or protein dimerization. We discuss mechanisms of h action as a transcriptional regulator.

Original language	English (US)
Pages (from-to)	3095-3103
Number of pages	9
Journal	The EMBO journal
Volume	8
Issue number	10
DOIs	https://doi.org/10.1002/j.1460-2075.1989.tb08461.x
State	Published - Oct 1989

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.1002/j.1460-2075.1989.tb08461.x

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title = "The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.",

abstract = "The Drosophila segmentation gene, hairy (h), acts to regulate embryonic segmentation and bristle pattern. We present the DNA sequence of the h gene and of h cDNAs, thereby deducing the organization of the h transcripts. The h gene encodes a 337 amino acid protein that acts in both embryonic segmentation and adult bristle patterning. The h protein includes a domain that shows extensive similarity to a domain of the proto-oncogene N-myc that may be involved in DNA binding and/or protein dimerization. We discuss mechanisms of h action as a transcriptional regulator.",

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AU - Rushlow, C. A.

AU - Hogan, A.

AU - Pinchin, S. M.

AU - Howe, K. M.

AU - Lardelli, M.

AU - Ish-Horowicz, D.

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Y1 - 1989/10

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The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

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