The dynamic activation of colicin Ia channels in planar bilayer lipid membrane

R. Cassia-Moura, A. Popescu, J. R S A Lima, C. A S Andrade, L. S. Ventura, K. S A Lima, J. Rinzel

Research output: Contribution to journalArticle

Abstract

Dynamic activation of ion channels formed by colicin Ia incorporated into a planar bilayer lipid membrane (BLM) was investigated by the voltage clamp technique using different step voltage stimuli. We have demonstrated a critical resting interval, Δt(c), between two identical successive voltage pulses. If the second pulse is applied within Δt(c), it produces a predictable current response. On the contrary, if the second pulse is applied after Δt(c), the current response cannot be reliably predicted. Computer simulations based on an idealized mathematical model, developed in this paper, qualitatively reproduce the system's dynamic responses to stimulus trains. The behavior of the ion channels, when the resting period exceeds Δt(c), may be interpreted as a transient gain or loss or resetting of memory, as revealed by a specific sequence of electrical pulses used for stimulation. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalJournal of Theoretical Biology
Volume206
Issue number2
DOIs
StatePublished - Sep 21 2000

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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  • Cite this

    Cassia-Moura, R., Popescu, A., Lima, J. R. S. A., Andrade, C. A. S., Ventura, L. S., Lima, K. S. A., & Rinzel, J. (2000). The dynamic activation of colicin Ia channels in planar bilayer lipid membrane. Journal of Theoretical Biology, 206(2), 235-241. https://doi.org/10.1006/jtbi.2000.2124