TY - JOUR
T1 - The dynamic activation of colicin Ia channels in planar bilayer lipid membrane
AU - Cassia-Moura, R.
AU - Popescu, A.
AU - Lima, J. R S A
AU - Andrade, C. A S
AU - Ventura, L. S.
AU - Lima, K. S A
AU - Rinzel, J.
N1 - Funding Information:
This work was completed at and partially supported by the Abdus Salam International Centre for Theoretical Physics, during the visit of Cassia-Moura and Popescu under the Associate Scheme, who greatly appreciate the technical support and stimulating working environment provided by all the sta! at the Centre.
Funding Information:
The experiments were partially performed at De-partamento de Bio"sica/UFPE. A part of this work was supported by grants from CNPq FACEPE and CAPES.
PY - 2000/9/21
Y1 - 2000/9/21
N2 - Dynamic activation of ion channels formed by colicin Ia incorporated into a planar bilayer lipid membrane (BLM) was investigated by the voltage clamp technique using different step voltage stimuli. We have demonstrated a critical resting interval, Δt(c), between two identical successive voltage pulses. If the second pulse is applied within Δt(c), it produces a predictable current response. On the contrary, if the second pulse is applied after Δt(c), the current response cannot be reliably predicted. Computer simulations based on an idealized mathematical model, developed in this paper, qualitatively reproduce the system's dynamic responses to stimulus trains. The behavior of the ion channels, when the resting period exceeds Δt(c), may be interpreted as a transient gain or loss or resetting of memory, as revealed by a specific sequence of electrical pulses used for stimulation. (C) 2000 Academic Press.
AB - Dynamic activation of ion channels formed by colicin Ia incorporated into a planar bilayer lipid membrane (BLM) was investigated by the voltage clamp technique using different step voltage stimuli. We have demonstrated a critical resting interval, Δt(c), between two identical successive voltage pulses. If the second pulse is applied within Δt(c), it produces a predictable current response. On the contrary, if the second pulse is applied after Δt(c), the current response cannot be reliably predicted. Computer simulations based on an idealized mathematical model, developed in this paper, qualitatively reproduce the system's dynamic responses to stimulus trains. The behavior of the ion channels, when the resting period exceeds Δt(c), may be interpreted as a transient gain or loss or resetting of memory, as revealed by a specific sequence of electrical pulses used for stimulation. (C) 2000 Academic Press.
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U2 - 10.1006/jtbi.2000.2124
DO - 10.1006/jtbi.2000.2124
M3 - Article
C2 - 10966761
AN - SCOPUS:0034699409
SN - 0022-5193
VL - 206
SP - 235
EP - 241
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 2
ER -