Abstract
Lesioning of serotonergic (5-HT) fibers using 5,7-dihydroxytryptamine (5,7-DHT) in one of the two median raphe-hippocampal pathways induced homotypic sprouting from the other. We have utilized this model with the horseradish peroxidase (HRP) tracing technique to test the effects of an adrenal corticosteroid-corticosterone on homotypic sprouting in female adult rats. Removal of the adrenal glands does not interfere with the 5,7-DHT destruction of 5-HT fibers observed at 3 days. However, the animals without circulating adrenal steroids do not show the increase of the HRP-labeled cells normally seen 21 days after the 5,7-DHT lesions. Furthermore, s.c. implantation of corticosterone pellets was able to completely restore homotypic sprouting of 5-HT fibers in the hippocampus.
Original language | English (US) |
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Pages (from-to) | 111-116 |
Number of pages | 6 |
Journal | Neuroscience letters |
Volume | 54 |
Issue number | 2-3 |
DOIs | |
State | Published - 1985 |
Keywords
- 5,7-dihydroxytryptamine
- adrenalectomy
- corticosterone
- hippocampus
- homotypic sprouting
- raphe
- serotonin
ASJC Scopus subject areas
- General Neuroscience