The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes

André Mercanzini; Sai Reddy; Marc Boers; Diana Velluto; Arnaud Bertsch; Jeffrey Hubbell; Philippe Renaud

doi:10.1109/SENSOR.2007.4300399

The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes

André Mercanzini, Sai Reddy, Marc Boers, Diana Velluto, Arnaud Bertsch, Jeffrey Hubbell, Philippe Renaud

Chemical and Biomolecular Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This study describes how drug eluting coatings affect the signal quality of implantable microelectrodes. Polyimide-Platinum neural probes were microfabricated and coated with a biodegradable polymer loaded with drug eluting nanoparticles. Electrical impedance spectroscopy was used to study how the coating affects electrical recording and stimulation characteristics. The measurements were performed in vitro and it was found that the biodegradable film slightly modified the measured impedance phase by +3° at 10kHz but not the magnitude. This change in impedance is permanent but does not adversely affect the recording and stimulation characteristics of the device. This result demonstrates the compatibility of controlled release drug coatings with neural probes.

Original language	English (US)
Title of host publication	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	1377-1380
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2007.4300399
State	Published - 2007
Event	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 - Lyon, France Duration: Jun 10 2007 → Jun 14 2007

Publication series

Name	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems

Conference

Conference	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
Country/Territory	France
City	Lyon
Period	6/10/07 → 6/14/07

Keywords

Drug delivery
Electrical impedance spectroscopy
Neural probes

ASJC Scopus subject areas

Control and Systems Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/SENSOR.2007.4300399

Cite this

Mercanzini, A., Reddy, S., Boers, M., Velluto, D., Bertsch, A., Hubbell, J., & Renaud, P. (2007). The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 1377-1380). Article 4300399 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300399

The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes. / Mercanzini, André; Reddy, Sai; Boers, Marc et al.
TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 1377-1380 4300399 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Mercanzini, A, Reddy, S, Boers, M, Velluto, D, Bertsch, A, Hubbell, J & Renaud, P 2007, The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes. in TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems., 4300399, TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 1377-1380, 4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07, Lyon, France, 6/10/07. https://doi.org/10.1109/SENSOR.2007.4300399

Mercanzini A, Reddy S, Boers M, Velluto D, Bertsch A, Hubbell J et al. The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 1377-1380. 4300399. (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2007.4300399

Mercanzini, André ; Reddy, Sai ; Boers, Marc et al. / The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes. TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. pp. 1377-1380 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

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The effect of biodegradable drug release coatings on the electrical characteristics of neural electrodes

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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