The effect of brain-derived neurotrophic factor on periodontal furcation defects

Ryo Jimbo, Nick Tovar, Malvin N. Janal, Ramy Mousa, Charles Marin, Daniel Yoo, Hellen S. Teixeira, Rodolfo B. Anchieta, Estevam A. Bonfante, Akihiro Konishi, Katsuhiro Takeda, Hidemi Kurihara, Paulo G. Coelho

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This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 μg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 μg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 μg/ml) in saline. The healing status for all groups was observed at different time-points with micro computed tomography. The animals were euthanized after 11 weeks, and the tooth-bone specimens were subjected to histologic processing. The results showed that all groups seemed to successfully regenerate the alveolar buccal bone, however, only Group A regenerated the entire periodontal tissue, i.e., alveolar bone, cementum and periodontal ligament. It is suggested that the use of BDNF in combination with a scaffold such as the hyaluronic acid in periodontal furcation defects may be an effective treatment option.

Original languageEnglish (US)
Article numbere84845
JournalPloS one
Issue number1
StatePublished - Jan 14 2014

ASJC Scopus subject areas

  • General


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