TY - JOUR
T1 - The effect of chemical modification on the solution structure of derivatives of substance P
T2 - Nuclear magnetic resonance study of substituted and retroinverso analogues
AU - Esposito, Gennaro
AU - Settembri, Luigi
AU - Viscomi, Giuseppe C.
AU - Niccolai, Neri
PY - 1988
Y1 - 1988
N2 - Four derivatives of the bioactive fragment 6-11 of Substance P were characterized by means of one- and two-dimensional 1H n.m.r. spectroscopy. Indirect evidence of backbone folding for these hexapeptides was given by temperature coefficients and paramagnetic relaxation rate enhancements of the amide protons. Chemical modifications were found to modulate the solution structure. Retro-inversion caused some conformational changes and a correlation between these structural variations and the relative biological activities was attempted.
AB - Four derivatives of the bioactive fragment 6-11 of Substance P were characterized by means of one- and two-dimensional 1H n.m.r. spectroscopy. Indirect evidence of backbone folding for these hexapeptides was given by temperature coefficients and paramagnetic relaxation rate enhancements of the amide protons. Chemical modifications were found to modulate the solution structure. Retro-inversion caused some conformational changes and a correlation between these structural variations and the relative biological activities was attempted.
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U2 - 10.1039/P29880001313
DO - 10.1039/P29880001313
M3 - Article
AN - SCOPUS:1842317251
SN - 1472-779X
SP - 1313
EP - 1318
JO - Journal of the Chemical Society, Perkin Transactions 2
JF - Journal of the Chemical Society, Perkin Transactions 2
IS - 7
ER -