TY - JOUR
T1 - The Effect of Glucose Levels Prior to Hematopoietic Cell Transplantation on Post-Transplant Complications and Health Resource Utilization
AU - Steinberg, Amir
AU - Van Cleave, Janet H.
AU - Parikh, Anish B.
AU - Moshier, Erin
AU - Ru, Meng
AU - Marks, Douglas
AU - Montelibano, Antoinette
AU - Philpott, Amanda
AU - Garner, Kourtney
AU - Hammer, Marilyn J.
N1 - Funding Information:
Funding for data and statistical analysis was provided by the Tisch Cancer Institute and by NCI Cancer Center Support Grant P30 CA196521-01.
Publisher Copyright:
© International Journal of Hematology-Oncology and Stem Cell Research. All rights reserved.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background: Abnormal blood glucose (BG) levels during hematopoietic cell transplantation (HCT) are associated with increased infections, delayed engraftment, and prolonged hospitalization, though little is known about these associations. Materials and Methods: We retrospectively evaluated mean BG levels in the week prior to HCT and subsequent outcomes for 852 HCTs at our hospital from 1/2009 � 12/2013 pertaining to 745 patients. Outcomes included infections (pneumonia, C. difficile, positive cultures, administration of antimicrobials, or neutropenic fever), time-to-engraftment (TTE), and quality indicators (30- and 90-day readmission rates [RR] and median length-of-stay [LOS]). Results: We retrospectively evaluated mean BG levels in the week prior to HCT and subsequent outcomes for 852 HCTs at our hospital from 1/2009 � 12/2013 pertaining to 745 patients. Outcomes included infections (pneumonia, C. difficile, positive cultures, administration of antimicrobials, or neutropenic fever), time-to-engraftment (TTE), and quality indicators (30- and 90-day readmission rates [RR] and median length-of-stay [LOS]). Conclusion: Pre-HCT BG trends may be a prognostic biomarker for adverse outcomes, and thus can help improve quality of care for HCT patients.
AB - Background: Abnormal blood glucose (BG) levels during hematopoietic cell transplantation (HCT) are associated with increased infections, delayed engraftment, and prolonged hospitalization, though little is known about these associations. Materials and Methods: We retrospectively evaluated mean BG levels in the week prior to HCT and subsequent outcomes for 852 HCTs at our hospital from 1/2009 � 12/2013 pertaining to 745 patients. Outcomes included infections (pneumonia, C. difficile, positive cultures, administration of antimicrobials, or neutropenic fever), time-to-engraftment (TTE), and quality indicators (30- and 90-day readmission rates [RR] and median length-of-stay [LOS]). Results: We retrospectively evaluated mean BG levels in the week prior to HCT and subsequent outcomes for 852 HCTs at our hospital from 1/2009 � 12/2013 pertaining to 745 patients. Outcomes included infections (pneumonia, C. difficile, positive cultures, administration of antimicrobials, or neutropenic fever), time-to-engraftment (TTE), and quality indicators (30- and 90-day readmission rates [RR] and median length-of-stay [LOS]). Conclusion: Pre-HCT BG trends may be a prognostic biomarker for adverse outcomes, and thus can help improve quality of care for HCT patients.
KW - Bone marrow transplant
KW - Glucose
KW - Health resource utilization
KW - Hyperglycemia
KW - Infection
KW - Patient readmission
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U2 - 10.18502/ijhoscr.v13i3.1270
DO - 10.18502/ijhoscr.v13i3.1270
M3 - Article
AN - SCOPUS:85071857563
SN - 1735-1243
VL - 13
SP - 122
EP - 131
JO - International Journal of Hematology-Oncology and Stem Cell Research
JF - International Journal of Hematology-Oncology and Stem Cell Research
IS - 3
ER -