The Effect of Glucose Levels Prior to Hematopoietic Cell Transplantation on Post-Transplant Complications and Health Resource Utilization

Amir Steinberg, Janet H. Van Cleave, Anish B. Parikh, Erin Moshier, Meng Ru, Douglas Marks, Antoinette Montelibano, Amanda Philpott, Kourtney Garner, Marilyn J. Hammer

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Abnormal blood glucose (BG) levels during hematopoietic cell transplantation (HCT) are associated with increased infections, delayed engraftment, and prolonged hospitalization, though little is known about these associations. Materials and Methods: We retrospectively evaluated mean BG levels in the week prior to HCT and subsequent outcomes for 852 HCTs at our hospital from 1/2009 � 12/2013 pertaining to 745 patients. Outcomes included infections (pneumonia, C. difficile, positive cultures, administration of antimicrobials, or neutropenic fever), time-to-engraftment (TTE), and quality indicators (30- and 90-day readmission rates [RR] and median length-of-stay [LOS]). Results: We retrospectively evaluated mean BG levels in the week prior to HCT and subsequent outcomes for 852 HCTs at our hospital from 1/2009 � 12/2013 pertaining to 745 patients. Outcomes included infections (pneumonia, C. difficile, positive cultures, administration of antimicrobials, or neutropenic fever), time-to-engraftment (TTE), and quality indicators (30- and 90-day readmission rates [RR] and median length-of-stay [LOS]). Conclusion: Pre-HCT BG trends may be a prognostic biomarker for adverse outcomes, and thus can help improve quality of care for HCT patients.

Original languageEnglish (US)
Pages (from-to)122-131
Number of pages10
JournalInternational Journal of Hematology-Oncology and Stem Cell Research
Volume13
Issue number3
DOIs
StatePublished - Jul 1 2019

Keywords

  • Bone marrow transplant
  • Glucose
  • Health resource utilization
  • Hyperglycemia
  • Infection
  • Patient readmission

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Transplantation

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