The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria

Yoshihito Naito, Takayuki Terukina, Silvia Galli, Yusuke Kozai, Stefan Vandeweghe, Tatsuaki Tagami, Tetsuya Ozeki, Tetsuo Ichikawa, Paulo G. Coelho, Ryo Jimbo

Research output: Contribution to journalArticle

Abstract

The present study describes the development of a microsphere capsule based on polylactide-co-glycolide (PLGA) loaded with simvastatin that was subsequently incorporated into synthetic bone cement. The osteogenic effect of simvastatin-loaded bone cement was in a critical sized defect in vivo to test the hypothesis the biologic response would be different depending on the dosage of simvastatin applied to bone cement. Our results showed that simvastatin loaded PLGA microspheres can be successfully obtained through O/W emulsion/solvent evaporation method with appropriate morphologic characteristics and high encapsulation efficiency for incorporation in bone cements. The biodegradable characteristic of the microspheres successfully presented a slow release and the duration of the release lasted for more than 1 month. The in vivo experiment revealed that the microspheres containing simvastatin significantly enhanced bone formation in the rabbit calvaria critical size defect.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume461
Issue number1-2
DOIs
StatePublished - Jan 30 2014

Keywords

  • Bone substitutions
  • Critical sized defect
  • PLGA microspheres
  • Simvastatin

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Naito, Y., Terukina, T., Galli, S., Kozai, Y., Vandeweghe, S., Tagami, T., Ozeki, T., Ichikawa, T., Coelho, P. G., & Jimbo, R. (2014). The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria. International Journal of Pharmaceutics, 461(1-2), 157-162. https://doi.org/10.1016/j.ijpharm.2013.11.046