TY - JOUR
T1 - The Effective Mutation Rate at Y Chromosome Short Tandem Repeats, with Application to Human Population-Divergence Time
AU - Zhivotovsky, Lev A.
AU - Underhill, Peter A.
AU - Cinnioǧlu, Cengiz
AU - Kayser, Manfred
AU - Morar, Bharti
AU - Kivisild, Toomas
AU - Scozzari, Rosaria
AU - Cruciani, Fulvio
AU - Destro-Bisol, Giovanni
AU - Spedini, Gabriella
AU - Chambers, Geoffrey K.
AU - Herrera, Rene J.
AU - Yong, Kiau Kiun
AU - Gresham, David
AU - Tournev, Ivailo
AU - Feldman, Marcus W.
AU - Kalaydjieva, Luba
N1 - Funding Information:
We thank Dr. David Modiano (University “La Sapienza,” Rome), for providing the Mossi samples; Dr. Antonel Olckers (Potchefstrum University for Christian Higher Education, Pretoria, South Africa), for the !Kung samples; and Dr. Erika Hagelberg (University of Oslo), for providing the Cook samples. We thank two anonymous reviewers for their helpful comments. Research was supported, in part, by National Institutes of Health grants R03 TW005540, GM 28016, and GM 28428 and by the Australian Research Council, the Wellcome Trust, the Max Planck Society (Germany), and Russian Foundation for Basic Research grant 01-04-48441. We thank Ms. Lisa Diamond for technical assistance in preparing this manuscript.
PY - 2004/1
Y1 - 2004/1
N2 - We estimate an effective mutation rate at an average Y chromosome short-tandem repeat locus as 6.9 × 10-4 per 25 years, with a standard deviation across loci of 5.7 × 10-4, using data on microsatellite variation within Y chromosome haplogroups defined by unique-event polymorphisms in populations with documented short-term histories, as well as comparative data on worldwide populations at both the Y chromosome and various autosomal loci. This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria.
AB - We estimate an effective mutation rate at an average Y chromosome short-tandem repeat locus as 6.9 × 10-4 per 25 years, with a standard deviation across loci of 5.7 × 10-4, using data on microsatellite variation within Y chromosome haplogroups defined by unique-event polymorphisms in populations with documented short-term histories, as well as comparative data on worldwide populations at both the Y chromosome and various autosomal loci. This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria.
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U2 - 10.1086/380911
DO - 10.1086/380911
M3 - Article
C2 - 14691732
AN - SCOPUS:9144274354
SN - 0002-9297
VL - 74
SP - 50
EP - 61
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 1
ER -