The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

R. I. Vogel, I. B. Lamster, S. A. Wechsler, B. Macedo, L. J. Hartley, J. A. Macedo

Research output: Contribution to journalArticlepeer-review

Abstract

A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximately twice the recommended daily allowances. Results indicate that although the group receiving ascorbate supplementation demonstrated a significant increase in plasma levels of the vitamin as compared to a placebo group, no significant differences with respect to PMN chemotaxis or responses to experimental gingivitis were found between the groups.

Original languageEnglish (US)
Pages (from-to)472-479
Number of pages8
JournalJournal of periodontology
Volume57
Issue number8
DOIs
StatePublished - Aug 1986

ASJC Scopus subject areas

  • Periodontics

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