The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

R. I. Vogel; I. B. Lamster; S. A. Wechsler; B. Macedo; L. J. Hartley; J. A. Macedo

doi:10.1902/jop.1986.57.8.472

The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

R. I. Vogel, I. B. Lamster, S. A. Wechsler, B. Macedo, L. J. Hartley, J. A. Macedo

Periodontology and Implant Dentistry

Research output: Contribution to journal › Article › peer-review

Abstract

A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximately twice the recommended daily allowances. Results indicate that although the group receiving ascorbate supplementation demonstrated a significant increase in plasma levels of the vitamin as compared to a placebo group, no significant differences with respect to PMN chemotaxis or responses to experimental gingivitis were found between the groups.

Original language	English (US)
Pages (from-to)	472-479
Number of pages	8
Journal	Journal of periodontology
Volume	57
Issue number	8
DOIs	https://doi.org/10.1902/jop.1986.57.8.472
State	Published - Aug 1986

ASJC Scopus subject areas

Periodontics

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10.1902/jop.1986.57.8.472

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The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

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