Abstract
Recent developments in the field of gene transcription regulation have unfolded a key role for actin as an important co-factor for all three eukaryotic RNA polymerases. In this review article we discuss the latest findings on actin in transcription of protein-coding and ribosomal genes, in complex with specific hnRNP proteins and a form of myosin 1ß which is entirely localized to the cell nucleus. Based on these recent studies, we propose a general model where actin may function in basal gene transcription as an allosteric regulator, to recruit transcriptional co-activators on active genes. A future challenge will be the identification of the polymerization state of actin in gene transcription and how it is mechanistically regulated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1051-1055 |
| Number of pages | 5 |
| Journal | Histology and Histopathology |
| Volume | 22 |
| Issue number | 7-9 |
| State | Published - Jul 2007 |
Keywords
- Nuclear actin
- Nuclear myosin
- RNA polymerase
- Ribonucleoproteins
- Transcription
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology