The function of actin in gene transcription

A. Obrdlik, A. Kukalev, Piergiorgio Percipalle

Research output: Contribution to journalReview articlepeer-review


Recent developments in the field of gene transcription regulation have unfolded a key role for actin as an important co-factor for all three eukaryotic RNA polymerases. In this review article we discuss the latest findings on actin in transcription of protein-coding and ribosomal genes, in complex with specific hnRNP proteins and a form of myosin 1ß which is entirely localized to the cell nucleus. Based on these recent studies, we propose a general model where actin may function in basal gene transcription as an allosteric regulator, to recruit transcriptional co-activators on active genes. A future challenge will be the identification of the polymerization state of actin in gene transcription and how it is mechanistically regulated.

Original languageEnglish (US)
Pages (from-to)1051-1055
Number of pages5
JournalHistology and Histopathology
Issue number7-9
StatePublished - Jul 2007


  • Nuclear actin
  • Nuclear myosin
  • RNA polymerase
  • Ribonucleoproteins
  • Transcription

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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