The generation of cortical interneurons

Renata Batista-Brito, Claire Ward, Gord Fishell

Research output: Chapter in Book/Report/Conference proceedingChapter


The mammalian telencephalon is responsible for many functions, which range from processing sensory information to learning, decision-making, and modulating emotional responses. The capacity of telencephalon to perform such a variety of functions likely relies on its neuronal diversity. GABAergic inhibitory interneurons, with their enormous multiplicity of subtypes, are a major contributor to this repertoire as they have remarkable diversity in morphology, physiology, and function. The central goal of this manuscript is to survey our present knowledge of how cortical interneuron subtypes are generated during development. We will start by briefly addressing the mature properties that differentiate between different major populations of cortical interneurons. We will then review the progressive events in development involved in the generation of interneuron diversity, beginning with their origin and specification, within the different subdomains of the subpallium. We will then explore the mechanisms by which interneurons migrate and mature in the early postnatal cortex. Finally, we will conclude by calling the reader's attention to the devastating consequences resulting from developmental failures in the formation of inhibitory circuits within the cortex.

Original languageEnglish (US)
Title of host publicationPatterning and Cell Type Specification in the Developing CNS and PNS
Subtitle of host publicationComprehensive Developmental Neuroscience, Second Edition
Number of pages19
ISBN (Electronic)9780128144053
ISBN (Print)9780128144060
StatePublished - Jan 1 2020


  • Interneurons
  • Martinotti cells
  • Parvalbumin
  • Somatostatin
  • Telencephalon
  • Vasointestinal protein

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'The generation of cortical interneurons'. Together they form a unique fingerprint.

Cite this