TY - JOUR
T1 - The genetics of early telencephalon patterning
T2 - Some assembly required
AU - Hébert, Jean M.
AU - Fishell, Gord
N1 - Funding Information:
We would like to apologize to the authors of the many studies that have not been mentioned owing to lack of space. We would like to thank the many members of the Hébert and Fishell laboratories who read and offered suggestions on this Review, especially Drs Rossignol, Machold, Sousa, Demarco and Karayannis. In addition we would like to thank J. Dasen and B. Rudy for their comments on earlier versions of this manuscript. This research was supported by US National Institutes of Health grants to J.H. and G.F., as well as by funding from the Simons Foundation to G.F. and from the McDonnell and Sinsheimer Foundations to J.H.
PY - 2008/9
Y1 - 2008/9
N2 - The immense range of human behaviours is rooted in the complex neural networks of the cerebrum. The creation of these networks depends on the precise integration of specific neuronal subtypes that are born in different regions of the telencephalon. Here, using the mouse as a model system, we review how these proliferative zones are established. Moreover, we discuss how these regions can be traced back in development to the function of a few key genes, including those that encode fibroblast growth factors (FGFs), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), forkhead box G1 (FOXG1), paired box 6 (PAX6) and LIM homeobox protein 2 (LHX2), that pattern the early telencephalon.
AB - The immense range of human behaviours is rooted in the complex neural networks of the cerebrum. The creation of these networks depends on the precise integration of specific neuronal subtypes that are born in different regions of the telencephalon. Here, using the mouse as a model system, we review how these proliferative zones are established. Moreover, we discuss how these regions can be traced back in development to the function of a few key genes, including those that encode fibroblast growth factors (FGFs), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), forkhead box G1 (FOXG1), paired box 6 (PAX6) and LIM homeobox protein 2 (LHX2), that pattern the early telencephalon.
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U2 - 10.1038/nrn2463
DO - 10.1038/nrn2463
M3 - Review article
C2 - 19143049
AN - SCOPUS:49949107386
SN - 1471-003X
VL - 9
SP - 678
EP - 685
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 9
ER -