The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease

Najib M. El-Sayed, Peter J. Myler, Daniella C. Bartholomeu, Daniel Nilsson, Gautam Aggarwal, Anh Nhi Tran, Elodie Ghedin, Elizabeth A. Worthey, Arthur L. Delcher, Gaëlle Blandin, Scott J. Westenberger, Elisabet Caler, Gustavo C. Cerqueira, Carole Branche, Brian Haas, Atashi Anupama, Erik Arner, Lena Åslund, Philip Attipoe, Esteban BontempiFrédéric Bringaud, Peter Burton, Eithon Cadag, David A. Campbell, Mark Carrington, Jonathan Crabtree, Hamid Darban, Jose Franco Da Silveira, Pieter De Jong, Kimberly Edwards, Paul T. Englund, Gholam Fazelina, Tamara Feldblyum, Marcela Ferella, Alberto Carlos Frasch, Keith Gull, David Horn, Lihua Hou, Yiting Huang, Ellen Kindlund, Michele Klingbeil, Sindy Kluge, Hean Koo, Daniela Lacerda, Mariano J. Levin, Hernan Lorenzi, Tin Louie, Carlos Renato Machado, Richard McCulloch, Alan McKenna, Yumi Mizuno, Jeremy C. Mottram, Siri Nelson, Stephen Ochaya, Kazutoyo Osoegawa, Grace Pai, Marilyn Parsons, Martin Pentony, Ulf Pettersson, Mihai Pop, Jose Luis Ramirez, Joel Rinta, Laura Robertson, Steven L. Salzberg, Daniel O. Sanchez, Amber Seyler, Reuben Sharma, Jyoti Shetty, Anjana J. Simpson, Ellen Sisk, Martti T. Tammi, Rick Tarleton, Santuza Teixeira, Susan Van Aken, Christy Vogt, Pauline N. Ward, Bill Wickstead, Jennifer Wortman, Owen White, Claire M. Fraser, Kenneth D. Stuart, Björn Andersson

Research output: Contribution to journalArticle

Abstract

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.

Original languageEnglish (US)
Pages (from-to)409-415+435
JournalScience
Volume309
Issue number5733
DOIs
StatePublished - Jul 15 2005

ASJC Scopus subject areas

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    El-Sayed, N. M., Myler, P. J., Bartholomeu, D. C., Nilsson, D., Aggarwal, G., Tran, A. N., Ghedin, E., Worthey, E. A., Delcher, A. L., Blandin, G., Westenberger, S. J., Caler, E., Cerqueira, G. C., Branche, C., Haas, B., Anupama, A., Arner, E., Åslund, L., Attipoe, P., ... Andersson, B. (2005). The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease. Science, 309(5733), 409-415+435. https://doi.org/10.1126/science.1112631