The high CO2-solubility of per-acetylated α-, β-, and γ-cyclodextrin

Vijay K. Potluri, Andrew D. Hamilton, Christos F. Karanikas, Steven E. Bane, Jianhang Xu, Eric J. Beckman, Robert M. Enick

Research output: Contribution to journalArticlepeer-review


Per-acetylated cyclic hexa-, hepta-, and octa-saccharide, (α-cyclodextrin octadecaacetate, β-cyclodextrin heneiicosaacetate and γ-cyclodextrin tetracosaacetate, respectively) exhibit melting point reduction and high solubility in dense CO2. Two-phase boundaries of the CO2-acetylated sugar mixtures were determined for per-acetylated cyclodextrin concentrations of 2-30wt.%. The dew-point locus of the CO2 per-acetylated cyclodextrin binary systems shifted to higher pressures as the number of saccharides in the acetylated cyclodextrin increased. The CO2-solubility of per-acetylated cyclodextrins was comparable to oligomers of poly(vinyl acetate) (PVAc) (the most CO2 soluble non-fluorous vinyl homopolymer) that contained an equivalent number of acetate groups. This very high degree of miscibility implies that the acyl groups of the per-acetylated cyclodextrins were readily accessible for favorable Lewis acid:Lewis base interactions with CO2. Upon depressurization, each per-acetylated cyclodextrin formed rigid, brittle foams within the vessel as the boiling per-acetylated cyclodextrin-rich phase solidified during the removal of CO2.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalFluid Phase Equilibria
Issue number2
StatePublished - Sep 1 2003


  • Acetylated cyclodextrin
  • CO-philes
  • Cyclodextrin
  • Supercritical carbon dioxide

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Physics and Astronomy
  • Physical and Theoretical Chemistry


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