The hippocampus as the switchboard between perception and memory

Matthias S. Treder, Ian Charest, Sebastian Michelmann, María Carmen Martín-Buro, Frédéric Roux, Fernando Carceller-Benito, Arturo Ugalde-Canitrot, David T. Rollings, Vijay Sawlani, Ramesh Chelvarajah, Maria Wimber, Simon Hanslmayr, Bernhard P. Staresina

Research output: Contribution to journalArticlepeer-review


Adaptive memory recall requires a rapid and flexible switch from external perceptual reminders to internal mnemonic representations. However, owing to the limited temporal or spatial resolution of brain imaging modalities used in isolation, the hippocampal–cortical dynamics supporting this process remain unknown. We thus employed an object-scene cued recall paradigm across two studies, including intracranial electroencephalography (iEEG) and high-density scalp EEG. First, a sustained increase in hippocampal high gamma power (55 to 110 Hz) emerged 500 ms after cue onset and distinguished successful vs. unsuccessful recall. This increase in gamma power for successful recall was followed by a decrease in hippocampal alpha power (8 to 12 Hz). Intriguingly, the hippocampal gamma power increase marked the moment at which extrahippocampal activation patterns shifted from perceptual cue toward mnemonic target representations. In parallel, source-localized EEG alpha power revealed that the recall signal progresses from hippocampus to posterior parietal cortex and then to medial prefrontal cortex. Together, these results identify the hippocampus as the switchboard between perception and memory and elucidate the ensuing hippocampal–cortical dynamics supporting the recall process.

Original languageEnglish (US)
Article numbere2114171118
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number50
StatePublished - Dec 14 2021


  • Gamma power
  • Hippocampus
  • Intracranial EEG
  • Memory
  • Recall

ASJC Scopus subject areas

  • General


Dive into the research topics of 'The hippocampus as the switchboard between perception and memory'. Together they form a unique fingerprint.

Cite this