TY - JOUR
T1 - The human cell atlas
AU - Human Cell Atlas Meeting Participants
AU - Regev, Aviv
AU - Teichmann, Sarah A.
AU - Lander, Eric S.
AU - Amit, Ido
AU - Benoist, Christophe
AU - Birney, Ewan
AU - Bodenmiller, Bernd
AU - Campbell, Peter
AU - Carninci, Piero
AU - Clatworthy, Menna
AU - Clevers, Hans
AU - Deplancke, Bart
AU - Dunham, Ian
AU - Eberwine, James
AU - Eils, Roland
AU - Enard, Wolfgang
AU - Farmer, Andrew
AU - Fugger, Lars
AU - Göttgens, Berthold
AU - Hacohen, Nir
AU - Haniffa, Muzlifah
AU - Hemberg, Martin
AU - Kim, Seung
AU - Klenerman, Paul
AU - Kriegstein, Arnold
AU - Lein, Ed
AU - Linnarsson, Sten
AU - Lundberg, Emma
AU - Lundeberg, Joakim
AU - Majumder, Partha
AU - Marioni, John C.
AU - Merad, Miriam
AU - Mhlanga, Musa
AU - Nawijn, Martijn
AU - Netea, Mihai
AU - Nolan, Garry
AU - Pe’er, Dana
AU - Phillipakis, Anthony
AU - Ponting, Chris P.
AU - Quake, Stephen
AU - Reik, Wolf
AU - Rozenblatt-Rosen, Orit
AU - Sanes, Joshua
AU - Satija, Rahul
AU - Schumacher, Ton N.
AU - Shalek, Alex
AU - Shapiro, Ehud
AU - Sharma, Padmanee
AU - Shin, Jay W.
AU - Stegle, Oliver
N1 - Funding Information:
Garry Nolan Department of Microbiology and Immunology, Stanford University, Stanford, United States Dana Pe’er Computational and Systems Biology Program, Sloan Kettering Institute, New York, United States Anthony Phillipakis Broad Institute of MIT and Harvard, Cambridge, United States Chris P Ponting MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom https://orcid.org/0000-0003-0202-7816 Steve Quake Department of Applied Physics and Department of Bioengineering, Stanford University, Stanford, United States; Chan Zuckerberg Biohub, San Francisco, United States Wolf Reik Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom; Epigenetics Programme, The Babraham Institute, Cambridge, United Kingdom; Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom Orit Rozenblatt-Rosen Broad Institute of MIT and Harvard, Cambridge, United States Joshua Sanes Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States https://orcid.org/0000-0001-8926-8836 Rahul Satija Department of Biology, New York University, New York, United States; New York Genome Center, New York University, New York, United States https://orcid.org/0000-0001-9448-8833 Ton N Schumacher Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands Alex Shalek Broad Institute of MIT and Harvard, Cambridge, United States; Institute for Medical Engineering & Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States; Ragon Institute of MGH, MIT and Harvard, Cambridge, United States Ehud Shapiro Department of Computer Science and Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel Padmanee Sharma Department of Genitourinary Medical Oncology, Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, United States Jay W Shin Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Japan Oliver Stegle EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom Michael Stratton Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom Michael JT Stubbington Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
Publisher Copyright:
© Regev et al.
PY - 2017/12/5
Y1 - 2017/12/5
N2 - The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.
AB - The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.
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U2 - 10.7554/eLife.27041
DO - 10.7554/eLife.27041
M3 - Article
C2 - 29206104
AN - SCOPUS:85040459896
VL - 6
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e27041
ER -