The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery

Charles W. Wolgemuth; Alexander Mogilner; George Oster

doi:10.1007/s00249-003-0344-5

The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery

Charles W. Wolgemuth, Alexander Mogilner, George Oster

Research output: Contribution to journal › Article › peer-review

Abstract

We combine the physics of gels with the hydrodynamics of two-phase fluids to construct a set of equations that describe the hydration dynamics of polyelectrolyte gels. We use the model to address three problems. First, we express the effective diffusion constants for neutral and charged spherically distributed gels in terms of microscopic parameters. Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release.

Original language	English (US)
Pages (from-to)	146-158
Number of pages	13
Journal	European Biophysics Journal
Volume	33
Issue number	2
DOIs	https://doi.org/10.1007/s00249-003-0344-5
State	Published - Apr 2004

Keywords

Diffusion constants
Drug release
Hydration dynamics
Nematode sperm cells
Polyelectrolyte gels

ASJC Scopus subject areas

Biophysics

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10.1007/s00249-003-0344-5

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title = "The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery",

abstract = "We combine the physics of gels with the hydrodynamics of two-phase fluids to construct a set of equations that describe the hydration dynamics of polyelectrolyte gels. We use the model to address three problems. First, we express the effective diffusion constants for neutral and charged spherically distributed gels in terms of microscopic parameters. Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release.",

keywords = "Diffusion constants, Drug release, Hydration dynamics, Nematode sperm cells, Polyelectrolyte gels",

author = "Wolgemuth, {Charles W.} and Alexander Mogilner and George Oster",

note = "Funding Information: Acknowledgements C.W. was supported by NSF grant 99-142. A.M. was supported by NSF grant DMS-1097746. G.O. was supported by NSF grant DMS-9972826. Tom Roberts and Murray Stewart provided us with important biological input on the Ascaris model. Dan Burfoot provided useful input on the drug delivery model. The authors especially thank Rami Tzafriri and Hans Weinberger and the referees for their valuable comments and for steering us to references we had missed.",

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doi = "10.1007/s00249-003-0344-5",

language = "English (US)",

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AU - Wolgemuth, Charles W.

AU - Mogilner, Alexander

AU - Oster, George

N1 - Funding Information: Acknowledgements C.W. was supported by NSF grant 99-142. A.M. was supported by NSF grant DMS-1097746. G.O. was supported by NSF grant DMS-9972826. Tom Roberts and Murray Stewart provided us with important biological input on the Ascaris model. Dan Burfoot provided useful input on the drug delivery model. The authors especially thank Rami Tzafriri and Hans Weinberger and the referees for their valuable comments and for steering us to references we had missed.

PY - 2004/4

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N2 - We combine the physics of gels with the hydrodynamics of two-phase fluids to construct a set of equations that describe the hydration dynamics of polyelectrolyte gels. We use the model to address three problems. First, we express the effective diffusion constants for neutral and charged spherically distributed gels in terms of microscopic parameters. Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release.

AB - We combine the physics of gels with the hydrodynamics of two-phase fluids to construct a set of equations that describe the hydration dynamics of polyelectrolyte gels. We use the model to address three problems. First, we express the effective diffusion constants for neutral and charged spherically distributed gels in terms of microscopic parameters. Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release.

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KW - Hydration dynamics

KW - Nematode sperm cells

KW - Polyelectrolyte gels

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JO - European Biophysics Journal

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The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery

Abstract

Keywords

ASJC Scopus subject areas

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