TY - JOUR
T1 - The impact of genomics on population genetics of parasitic diseases
AU - Hupalo, Daniel N.
AU - Bradic, Martina
AU - Carlton, Jane M.
N1 - Funding Information:
We thank Steven Sullivan for his excellent manuscript editing. This work was supported by National Institute of Allergy and Infectious Diseases , National Institutes of Health ( NIH ) grant U19AI089676 to JMC, and DNH was supported under Bioinformatics Administrative Supplement 5U19AI089676-04 REVISED and MB under R01AI097080 to P. Kissinger. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Parasites, defined as eukaryotic microbes and parasitic worms that cause global diseases of human and veterinary importance, span many lineages in the eukaryotic Tree of Life. Historically challenging to study due to their complicated life-cycles and association with impoverished settings, their inherent complexities are now being elucidated by genome sequencing. Over the course of the last decade, projects in large sequencing centers, and increasingly frequently in individual research labs, have sequenced dozens of parasite reference genomes and field isolates from patient populations. This 'tsunami' of genomic data is answering questions about parasite genetic diversity, signatures of evolution orchestrated through anti-parasitic drug and host immune pressure, and the characteristics of populations. This brief review focuses on the state of the art of parasitic protist genomics, how the peculiar genomes of parasites are driving creative methods for their sequencing, and the impact that next-generation sequencing is having on our understanding of parasite population genomics and control of the diseases they cause.
AB - Parasites, defined as eukaryotic microbes and parasitic worms that cause global diseases of human and veterinary importance, span many lineages in the eukaryotic Tree of Life. Historically challenging to study due to their complicated life-cycles and association with impoverished settings, their inherent complexities are now being elucidated by genome sequencing. Over the course of the last decade, projects in large sequencing centers, and increasingly frequently in individual research labs, have sequenced dozens of parasite reference genomes and field isolates from patient populations. This 'tsunami' of genomic data is answering questions about parasite genetic diversity, signatures of evolution orchestrated through anti-parasitic drug and host immune pressure, and the characteristics of populations. This brief review focuses on the state of the art of parasitic protist genomics, how the peculiar genomes of parasites are driving creative methods for their sequencing, and the impact that next-generation sequencing is having on our understanding of parasite population genomics and control of the diseases they cause.
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U2 - 10.1016/j.mib.2014.11.001
DO - 10.1016/j.mib.2014.11.001
M3 - Review article
C2 - 25461572
AN - SCOPUS:84918507089
SN - 1369-5274
VL - 23
SP - 49
EP - 54
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -