The in vivo effect of P-15 coating on early osseointegration

Paulo G. Coelho, Hellen S. Teixeira, Charles Marin, Lukasz Witek, Nick Tovar, Malvin N. Janal, Ryo Jimbo

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate mechanically and morphologically the effect of a specific peptide sequence P-15, when incorporated into implant surfaces. Three types of implants were used for the study: Group A: commercially pure titanium implant (blasted and acid etched) + electrochemical thin calcium phosphate deposition, Group B: commercially pure titanium implant (blasted and acid etched) + electrochemical thin calcium phosphate deposition + P-15 incorporation, and as control, Group C: commercially pure titanium implant (blasted and acid etched). After a topographical characterization, transcortical osteotomies were made, and all implant groups (102 implants per group) were randomly placed bilaterally in the tibiae of adult beagle dogs (n = 24). At, 1, 2, and 4 weeks post-surgery, the animals were sacrificed and the samples were retrieved for removal torque tests, for nano indentation, and for histomorphometrical analysis. The results (mean ± 95% CI) showed that Group B (34.4 ± 8.7%) presented statistically higher bone-to-implant contact than the other groups (A = 23.9 ± 7.8%; C = 21.7 ± 8.3%) at 1 week, indicating an enhanced osteogenesis due to the peptide incorporation. The results suggested that the incorporation of P-15 to implant surfaces increased its bioactivity and the effects were notable especially in the early stages of the healing process.

Original languageEnglish (US)
Pages (from-to)430-440
Number of pages11
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume102
Issue number3
DOIs
StatePublished - Apr 2014

Keywords

  • bioactivity
  • biomechanics
  • histomorphometry
  • in vivo
  • peptide

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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