The increased risk of cancer in obesity and type 2 diabetes: Potential mechanisms

Emily J. Gallagher, Brian A. Neel, Irini M. Antoniou, Shoshana Yakar, Derek LeRoith

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Theories on a connection between diabetes, obesity, and cancer have existed for over a century. In 1910, despite their elusive etiologies, Maynard hypothesized that a correlation between diabetes and cancer could exist, as both conditions were increasing in prevalence and had similar age distributions. In this chapter, we review the epidemiology linking obesity, diabetes, and cancer incidence and mortality and discuss some of the physiological changes that occur in obesity and type 2 diabetes that may contribute to cancer growth and metastases.

Original languageEnglish (US)
Title of host publicationPrinciples of Diabetes Mellitus
Subtitle of host publicationThird Edition
PublisherSpringer International Publishing
Pages731-753
Number of pages23
ISBN (Electronic)9783319187419
ISBN (Print)9783319187402
DOIs
StatePublished - Jul 7 2017

Keywords

  • Cancer
  • Diabetes
  • Dyslipidemia
  • Insulin
  • Insulinlike growth factor
  • Obesity

ASJC Scopus subject areas

  • Medicine(all)

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