The increased risk of cancer in obesity and type 2 diabetes: Potential mechanisms

Emily J. Gallagher; Brian A. Neel; Irini M. Antoniou; Shoshana Yakar; Derek LeRoith

doi:10.1007/978-3-319-18741-9_36

The increased risk of cancer in obesity and type 2 diabetes: Potential mechanisms

Emily J. Gallagher, Brian A. Neel, Irini M. Antoniou, Shoshana Yakar, Derek LeRoith

Molecular Pathobiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Theories on a connection between diabetes, obesity, and cancer have existed for over a century. In 1910, despite their elusive etiologies, Maynard hypothesized that a correlation between diabetes and cancer could exist, as both conditions were increasing in prevalence and had similar age distributions. In this chapter, we review the epidemiology linking obesity, diabetes, and cancer incidence and mortality and discuss some of the physiological changes that occur in obesity and type 2 diabetes that may contribute to cancer growth and metastases.

Original language	English (US)
Title of host publication	Principles of Diabetes Mellitus
Subtitle of host publication	Third Edition
Publisher	Springer International Publishing
Pages	731-753
Number of pages	23
ISBN (Electronic)	9783319187419
ISBN (Print)	9783319187402
DOIs	https://doi.org/10.1007/978-3-319-18741-9_36
State	Published - Jul 7 2017

Keywords

Cancer
Diabetes
Dyslipidemia
Insulin
Insulinlike growth factor
Obesity

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-319-18741-9_36

Cite this

@inbook{edef0ead60ff4cfb999603c3899d0841,

title = "The increased risk of cancer in obesity and type 2 diabetes: Potential mechanisms",

abstract = "Theories on a connection between diabetes, obesity, and cancer have existed for over a century. In 1910, despite their elusive etiologies, Maynard hypothesized that a correlation between diabetes and cancer could exist, as both conditions were increasing in prevalence and had similar age distributions. In this chapter, we review the epidemiology linking obesity, diabetes, and cancer incidence and mortality and discuss some of the physiological changes that occur in obesity and type 2 diabetes that may contribute to cancer growth and metastases.",

keywords = "Cancer, Diabetes, Dyslipidemia, Insulin, Insulinlike growth factor, Obesity",

author = "Gallagher, {Emily J.} and Neel, {Brian A.} and Antoniou, {Irini M.} and Shoshana Yakar and Derek LeRoith",

year = "2017",

month = jul,

day = "7",

doi = "10.1007/978-3-319-18741-9_36",

language = "English (US)",

isbn = "9783319187402",

pages = "731--753",

booktitle = "Principles of Diabetes Mellitus",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - The increased risk of cancer in obesity and type 2 diabetes

T2 - Potential mechanisms

AU - Gallagher, Emily J.

AU - Neel, Brian A.

AU - Antoniou, Irini M.

AU - Yakar, Shoshana

AU - LeRoith, Derek

PY - 2017/7/7

Y1 - 2017/7/7

N2 - Theories on a connection between diabetes, obesity, and cancer have existed for over a century. In 1910, despite their elusive etiologies, Maynard hypothesized that a correlation between diabetes and cancer could exist, as both conditions were increasing in prevalence and had similar age distributions. In this chapter, we review the epidemiology linking obesity, diabetes, and cancer incidence and mortality and discuss some of the physiological changes that occur in obesity and type 2 diabetes that may contribute to cancer growth and metastases.

AB - Theories on a connection between diabetes, obesity, and cancer have existed for over a century. In 1910, despite their elusive etiologies, Maynard hypothesized that a correlation between diabetes and cancer could exist, as both conditions were increasing in prevalence and had similar age distributions. In this chapter, we review the epidemiology linking obesity, diabetes, and cancer incidence and mortality and discuss some of the physiological changes that occur in obesity and type 2 diabetes that may contribute to cancer growth and metastases.

KW - Cancer

KW - Diabetes

KW - Dyslipidemia

KW - Insulin

KW - Insulinlike growth factor

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85064463759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064463759&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-18741-9_36

DO - 10.1007/978-3-319-18741-9_36

M3 - Chapter

AN - SCOPUS:85064463759

SN - 9783319187402

SP - 731

EP - 753

BT - Principles of Diabetes Mellitus

PB - Springer International Publishing

ER -

The increased risk of cancer in obesity and type 2 diabetes: Potential mechanisms

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this