The induction of c-Fos in the NTS after taste aversion learning is not correlated with measures of conditioned fear

Glenn E. Schafe, Joseph E. LeDoux, Douglas A. Fitts, Todd E. Thiele, Ilene L. Bernstein

Research output: Contribution to journalArticle

Abstract

The induction of c-Fos-like immunoreactivity (c-FLI) in the nucleus of the solitary tract (NTS) has been shown to be correlated with behavioral expression of a conditioned taste aversion (CTA). However, because this cellular response is also dependent on an intact amygdala, it may represent the activation of a stress-related autonomic response. The present experiments addressed this possibility by evaluating the correlation between c-FLI in the intermediate division of the NTS (iNTS) and 2 measures of conditioned fear: freezing and changes in mean arterial pressure (MAP) and heart rate (HR). Exposure to the taste conditioned stimulus (CS) resulted in a marked induction of c-FLI in the iNTS, whereas exposure to a fear CS did not. Further, exposure to a taste CS did not selectively lead to increases in MAP or HR. Results suggest that induction of c-FLI in the iNTS may reflect the activation of a cell population whose function is unique to the CTA paradigm.

Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
JournalBehavioral Neuroscience
Volume114
Issue number1
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Behavioral Neuroscience

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