The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues

A. H. Hielscher, S. L. Jacques, Lihong Wang, F. K. Tittel

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The applicability of diffusion theory for the determination of tissue optical properties from time-resolved reflectance spectroscopy is investigated. Analytical expressions from diffusion theory using the three most commonly assumed boundary conditions at the air-tissue interface are compared with time-resolved Monte Carlo simulations and measurements on tissue phantoms. The effects of the choice of the boundary conditions on the accuracy of the findings for the optical parameters are quantified, and criteria for accurate curve-fitting algorithms are developed.

    Original languageEnglish (US)
    Article number013
    Pages (from-to)1957-1975
    Number of pages19
    JournalPhysics in Medicine and Biology
    Volume40
    Issue number11
    DOIs
    StatePublished - 1995

    ASJC Scopus subject areas

    • Radiological and Ultrasound Technology
    • Radiology Nuclear Medicine and imaging

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