TY - JOUR
T1 - The Influence of Implant Design Features on the Bone Healing Pathway
T2 - An Experimental Study in Sheep
AU - Bergamo, Edmara T.P.
AU - de Oliveira, Paula G.F.P.
AU - Jimbo, Ryo
AU - Neiva, Rodrigo
AU - Gil, Luiz F.
AU - Tovar, Nick
AU - Witek, Lukasz
AU - Bonfante, Estevam A.
AU - Coelho, Paulo G.
N1 - Funding Information:
This study was supported by an FAPESP grant (2012/19078-7 and 2021/06730-7) and scholarship (2019/08693-1 and BEPE 2021/08018-2); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grants (307255/2021-2 and 434487/2018-0); and CAPES Finance Code 001. The authors declare no conflicts of interest.
Publisher Copyright:
© 2023 by Quintessence Publishing Co Inc.
PY - 2023/5
Y1 - 2023/5
N2 - This study evaluated how implant design features influence osseointegration. Two implant macrogeometries and surface treatments were evaluated: (1) progressive buttress threads with an SLActive surface (SLActive/BL), and (2) inner and outer trapezoidal threads with a nanohydroxyapatite coating over a dual acid-etched surface (Nano/U). Implants were placed in the right ilium of 12 sheep, and histologic and -metric analyses were conducted after 12 weeks. Percentages of bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) within the threads were quantified. Histologically, the SLActive/BL group showed greater and more intimate BIC than the Nano/U group. In contrast, Nano/U group depicted woven bone formation within the healing chambers, between the osteotomy wall and implant threads, and bone remodeling was evident at the outer thread tip. Significantly higher BAFO was seen in the Nano/U group than the SLActive/BL group at 12 weeks (P < .042). Different implant design features influenced the osseointegration pathway, supporting further investigations to describe the differences and clinical performance.
AB - This study evaluated how implant design features influence osseointegration. Two implant macrogeometries and surface treatments were evaluated: (1) progressive buttress threads with an SLActive surface (SLActive/BL), and (2) inner and outer trapezoidal threads with a nanohydroxyapatite coating over a dual acid-etched surface (Nano/U). Implants were placed in the right ilium of 12 sheep, and histologic and -metric analyses were conducted after 12 weeks. Percentages of bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) within the threads were quantified. Histologically, the SLActive/BL group showed greater and more intimate BIC than the Nano/U group. In contrast, Nano/U group depicted woven bone formation within the healing chambers, between the osteotomy wall and implant threads, and bone remodeling was evident at the outer thread tip. Significantly higher BAFO was seen in the Nano/U group than the SLActive/BL group at 12 weeks (P < .042). Different implant design features influenced the osseointegration pathway, supporting further investigations to describe the differences and clinical performance.
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U2 - 10.11607/prd.5438
DO - 10.11607/prd.5438
M3 - Article
C2 - 37141075
AN - SCOPUS:85159552753
SN - 0198-7569
VL - 43
SP - 337
EP - 343
JO - International Journal of Periodontics and Restorative Dentistry
JF - International Journal of Periodontics and Restorative Dentistry
IS - 3
ER -