The Institutional Learning Curve of Magnetic Resonance Imaging-Ultrasound Fusion Targeted Prostate Biopsy: Temporal Improvements in Cancer Detection in 4 Years

Xiaosong Meng, Andrew B. Rosenkrantz, Richard Huang, Fang Ming Deng, James S. Wysock, Marc A. Bjurlin, William C. Huang, Herbert Lepor, Samir S. Taneja

    Research output: Contribution to journalArticle

    Abstract

    Purpose: While magnetic resonance imaging-ultrasound fusion targeted biopsy allows for improved detection of clinically significant prostate cancer, a concerning amount of clinically significant disease is still missed. We hypothesized that a number of these misses are due to the learning curve associated with magnetic resonance imaging-ultrasound fusion targeted biopsy. We report the results of repeat magnetic resonance imaging-ultrasound fusion targeted biopsy in men with continued suspicion for cancer and the institutional learning curve in the detection of clinically significant prostate cancer with time. Materials and Methods: We analyzed the records of 1,813 prostate biopsies in a prospectively acquired cohort of men who presented for prostate biopsy in a 4-year period. All men were offered prebiopsy magnetic resonance imaging and were assigned a maximum PI-RADS™ (Prostate Imaging Reporting and Data System version 2) score. Biopsy outcomes in men with a suspicious region of interest were compared. The relationship between time and clinically significant prostate cancer detection was analyzed. Results: The clinically significant prostate cancer detection rate increased 26% with time in men with a PI-RADS 4/5 region of interest. On repeat magnetic resonance imaging-ultrasound fusion targeted biopsy in men with continued suspicion for cancer 53% of those with a PI-RADS 4/5 region of interest demonstrated clinically significant discordance from the initial magnetic resonance imaging-ultrasound fusion targeted biopsy compared to only 23% with a PI-RADS 1/2 region of interest. Significantly less clinically significant prostate cancer was missed or under graded in the most recent biopsies compared to the earliest biopsies. Conclusions: The high upgrade rate on repeat magnetic resonance imaging-ultrasound fusion targeted biopsy and the increasing cancer detection rate with time show the significant learning curve associated with magnetic resonance imaging-ultrasound fusion targeted biopsy. Men with low risk or negative biopsies with a persistent, concerning region of interest should be promptly rebiopsied. Improved targeting accuracy with operator experience can help decrease the number of missed cases of clinically significant prostate cancer.

    Original languageEnglish (US)
    Pages (from-to)1022-1029
    Number of pages8
    JournalJournal of Urology
    Volume200
    Issue number5
    DOIs
    StatePublished - Nov 2018

    Keywords

    • image-guided biopsy
    • learning curve
    • magnetic resonance imaging
    • prostatic neoplasms
    • ultrasonography

    ASJC Scopus subject areas

    • Urology

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    Meng, X., Rosenkrantz, A. B., Huang, R., Deng, F. M., Wysock, J. S., Bjurlin, M. A., Huang, W. C., Lepor, H., & Taneja, S. S. (2018). The Institutional Learning Curve of Magnetic Resonance Imaging-Ultrasound Fusion Targeted Prostate Biopsy: Temporal Improvements in Cancer Detection in 4 Years. Journal of Urology, 200(5), 1022-1029. https://doi.org/10.1016/j.juro.2018.06.012