The intricate role of growth hormone in metabolism

Archana Vijayakumar, Shoshana Yakar, Derek LeRoith

Research output: Contribution to journalReview articlepeer-review


Growth hormone (GH), a master regulator of somatic growth, also regulates carbohydrate and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 (IGF-1). Data from human and rodent studies reveal the importance of GH in insulin synthesis and secretion, lipid metabolism and body fat remodeling. In this review, we will summarize the tissue-specific metabolic effects of GH, with emphasis on recent targets identified to mediate these effects. Furthermore, we will discuss what role GH plays in obesity and present possible mechanisms by which this may occur.

Original languageEnglish (US)
Article numberArticle 32
JournalFrontiers in Endocrinology
Issue numberSEP
StatePublished - 2011


  • Carbohydrates
  • Growth hormone
  • Insulin resistance
  • Lipids
  • Metabolism
  • Tissue-specific

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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