The intrinsically restructured fovea is correlated with contrast sensitivity loss in Parkinson’s disease

Elmar H. Pinkhardt, Yin Ding, Samantha Slotnick, Jan Kassubek, Albert C. Ludolph, Sofya Glazman, Ivan Selesnick, Ivan Bodis-Wollner

Research output: Contribution to journalArticlepeer-review

Abstract

Foveal structure that is specified by the thickness, depth and the overall shape of the fovea is a promising tool to qualify and quantify retinal pathology in Parkinson’s disease. To determine the model variable that is best suited for discriminating Parkinson’s disease eyes from those of healthy controls and to assess correlations between impaired contrast sensitivity and foveal shape we characterized the fovea in 48 Parkinson’s disease patients and 45 control subjects by optical coherence tomography (OCT). The model quantifies structural changes in the fovea of Parkinson’s disease patients that are correlated with a decline in contrast sensitivity. Retinal foveal remodeling may serve as a parameter for vision deficits in Parkinson’s disease. Whether foveal remodeling reflects dopaminergic driven pathology or rather both dopaminergic and non-dopaminergic pathology has to be investigated in longitudinal studies.

Original languageEnglish (US)
Pages (from-to)1275-1283
Number of pages9
JournalJournal of Neural Transmission
Volume127
Issue number9
DOIs
StatePublished - Sep 1 2020

Keywords

  • Contrast sensitivity
  • Optical coherence tomography
  • Parkinson’s disease
  • Retinal foveal remodeling

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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