The intrinsically restructured fovea is correlated with contrast sensitivity loss in Parkinson’s disease

Elmar H. Pinkhardt; Yin Ding; Samantha Slotnick; Jan Kassubek; Albert C. Ludolph; Sofya Glazman; Ivan Selesnick; Ivan Bodis-Wollner

doi:10.1007/s00702-020-02224-9

The intrinsically restructured fovea is correlated with contrast sensitivity loss in Parkinson’s disease

Elmar H. Pinkhardt, Yin Ding, Samantha Slotnick, Jan Kassubek, Albert C. Ludolph, Sofya Glazman, Ivan Selesnick, Ivan Bodis-Wollner

Research output: Contribution to journal › Article › peer-review

Abstract

Foveal structure that is specified by the thickness, depth and the overall shape of the fovea is a promising tool to qualify and quantify retinal pathology in Parkinson’s disease. To determine the model variable that is best suited for discriminating Parkinson’s disease eyes from those of healthy controls and to assess correlations between impaired contrast sensitivity and foveal shape we characterized the fovea in 48 Parkinson’s disease patients and 45 control subjects by optical coherence tomography (OCT). The model quantifies structural changes in the fovea of Parkinson’s disease patients that are correlated with a decline in contrast sensitivity. Retinal foveal remodeling may serve as a parameter for vision deficits in Parkinson’s disease. Whether foveal remodeling reflects dopaminergic driven pathology or rather both dopaminergic and non-dopaminergic pathology has to be investigated in longitudinal studies.

Original language	English (US)
Pages (from-to)	1275-1283
Number of pages	9
Journal	Journal of Neural Transmission
Volume	127
Issue number	9
DOIs	https://doi.org/10.1007/s00702-020-02224-9
State	Published - Sep 1 2020

Keywords

Contrast sensitivity
Optical coherence tomography
Parkinson’s disease
Retinal foveal remodeling

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/s00702-020-02224-9

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abstract = "Foveal structure that is specified by the thickness, depth and the overall shape of the fovea is a promising tool to qualify and quantify retinal pathology in Parkinson{\textquoteright}s disease. To determine the model variable that is best suited for discriminating Parkinson{\textquoteright}s disease eyes from those of healthy controls and to assess correlations between impaired contrast sensitivity and foveal shape we characterized the fovea in 48 Parkinson{\textquoteright}s disease patients and 45 control subjects by optical coherence tomography (OCT). The model quantifies structural changes in the fovea of Parkinson{\textquoteright}s disease patients that are correlated with a decline in contrast sensitivity. Retinal foveal remodeling may serve as a parameter for vision deficits in Parkinson{\textquoteright}s disease. Whether foveal remodeling reflects dopaminergic driven pathology or rather both dopaminergic and non-dopaminergic pathology has to be investigated in longitudinal studies.",

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author = "Pinkhardt, {Elmar H.} and Yin Ding and Samantha Slotnick and Jan Kassubek and Ludolph, {Albert C.} and Sofya Glazman and Ivan Selesnick and Ivan Bodis-Wollner",

note = "Funding Information: A. Markopoulou from NorthShore University Health System, Evanston IL, USA participated in the study. Due to methodological reasons only the measurements from Ulm University were used for the final evaluation of the data. Funding Information: The research was supported by the Michael J. Fox Foundations for Parkinson{\textquoteright}s Research. Acknowledgements Publisher Copyright: {\textcopyright} 2020, Springer-Verlag GmbH Austria, part of Springer Nature.",

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AU - Glazman, Sofya

AU - Selesnick, Ivan

AU - Bodis-Wollner, Ivan

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The intrinsically restructured fovea is correlated with contrast sensitivity loss in Parkinson’s disease

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Keywords

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