The isolation and sequence analysis of vasoactive intestinal peptide from a ganglioneuroblastoma

N. W. Bunnett, J. R. Reeve, R. Dimaline, J. E. Shively, D. Hawke, J. H. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

A ganglioneuroblastoma was excised at surgery from a 1-yr-old girl with severe watery diarrhea. The tumor, weighing 1 g, was extracted in trifluoracetic acid and contained 8.3 nmol immunoreactive vasoactive intestinal peptide. The peptide was isolated by affinity chromatography and high pressure liquid chromatography and was found to be identical to porcine vasoactive intestinal peptide by amino acid analysis and microsequence analysis.

Original languageEnglish (US)
Pages (from-to)1133-1137
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume59
Issue number6
DOIs
StatePublished - Dec 1984

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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