The kinetics of monazomycin-induced voltage-dependent conductance: II. Theory and a demonstration of a form of memory

Robert U. Muller, Gary Orin, Charles S. Peskin

Research output: Contribution to journalArticlepeer-review

Abstract

The empirical differential equation that describes the kinetics of monazomycin-induced voltage-dependent conductance is derived using a standard chemical kinetic formulation and the assumption that monazomycin entry into and exit from the membrane is autocatalytic. The predicted form of gating currents is shown and numerical calculations for this process are made using a range of values for two unmeasured variables. A form of "memory" is then demonstrated, along with the ability of the theoretical equation to explain the nature of the memory.

Original languageEnglish (US)
Pages (from-to)201-229
Number of pages29
JournalJournal of General Physiology
Volume78
Issue number2
DOIs
StatePublished - Aug 1 1981

ASJC Scopus subject areas

  • Physiology

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